Clone B-ly7 recognizes an integrin containing the aE subunit which dimerizes with the b7 chain, present on hairy leukemia cells, to form the HML-1 (human mucosal lymphocyte) antigen. Clone B-ly7 is strongly reactive with hairy cell leukemia (HCL), activated monocytes, a subset of activated T and B cells (subtype of B cell chronic lymphocytic leukaemia), but not with other B cell leukemias or lymphomas. Testing by flow cytometry using a 'lyse-wash' method on a cell suspension containing HCL cells showed the following values expressed in terms of % of the total cell count: Product code: AM39027FC-N (anti-CD103 FITC) Mean % positive: 91,3 S.D.: 3,30 % CV: 3,61
The function of the CD103 integrin is related to T cell interaction with epithelium and to T cell adhesion. CD103 is expressed primarily on intra-epithelial lymphocytes and on 1-2 % of peripheral blood lymphocytes. Cellular expression: Hairy Cell Leukemia (strong), subset activated T and B cells, activated monocytes.Synonyms: HML-1 antigen, ITGAE, Integrin alpha-E, Integrin alpha-IEL, Mucosal lymphocyte 1 antigen