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CD130/gp130 antibody (FITC)
IL6ST
Reactivity: Human
FACS
Host: Mouse
Monoclonal
B-R3
FITC
Product Details anti-CD130/gp130 Antibody (FITC)
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Target
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CD130/gp130 (IL6ST)
(Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))
Reactivity
All reactivities for CD130/gp130 antibodies
Human
Host
All hosts for CD130/gp130 antibodies
Mouse
Clonality
All clonalities for CD130/gp130 antibodies
Monoclonal
Conjugate
All conjugates for CD130/gp130 antibodies
This CD130/gp130 antibody is conjugated to FITC
Application
All applications for CD130/gp130 antibodies
Flow Cytometry (FACS)
Specificity
Recognises the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein.
Cross-Reactivity (Details)
Species reactivity (tested):Human.
Purification
Ion Exchange Chromatography
Immunogen
Natural soluble gp130.
Clone
B-R3
Isotype
IgG2a
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
PBS containing 0.09 % Sodium Azide as preservative and 5 % BSA as stabilizer
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for CD130/gp130
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Target
CD130/gp130 (IL6ST)
(Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))
Alternative Name
CD130 / IL6ST (IL6ST Products )
Synonyms
CD130 antibody, CDW130 antibody, GP130 antibody, IL-6RB antibody, 5133400A03Rik antibody, AA389424 antibody, BB405851 antibody, D13Ertd699e antibody, gp130 antibody, Ac1055 antibody, Gp130 antibody, Il-6rb antibody, IL-6 antibody, interleukin 6 signal transducer antibody, IL6ST antibody, Il6st antibody, il6st antibody
Background
CD130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.Synonyms: IL-6R-beta, IL6 receptor beta, Interleukin-6 receptor subunit beta
Gene ID
3572
NCBI Accession
NP_002175
UniProt
P40189
Pathways
JAK-STAT Signaling , Cellular Glucan Metabolic Process , Autophagy , Smooth Muscle Cell Migration , Cancer Immune Checkpoints
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