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CD19 antibody (CD19 Molecule) (PerCP)

Details for Product anti-CD19 Antibody No. ABIN1105978, Supplier: Login to see
Antigen
  • CD19
  • AW495831
  • B4
  • CVID3
Alternatives
anti-Human CD19 antibody for Immunoprecipitation
Reactivity
Human
688
367
40
13
8
3
2
Host
Mouse
603
244
154
11
2
Clonality (Clone)
Monoclonal ()
Conjugate
This CD19 antibody is conjugated to PerCP
118
112
81
70
24
24
17
14
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12
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2
1
1
1
1
1
1
1
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1
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1
Application
Flow Cytometry (FACS)
735
160
145
116
102
82
51
46
46
37
24
18
9
7
4
4
4
4
4
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2
2
1
1
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1
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Clone HD37
Isotype IgG1
Specificity Clone HD37 is specific for CD19, it recognizes a 95 kDa transmembrane glycoprotein. Testing by flow cytometry using a 'lyse-wash' method on whole blood from healthy donors showed the following values expressed in terms of % of the total lymphocyte count: Product code: AM39014AC-N (anti-CD19 APC) n: 9 Mean % positive: 9,16 S.D.: 1,95 % CV: 21,31 ------------------------------------------ Product code: AM39014FC-N (anti-CD19 FITC) n: 9 Mean % positive: 10,80 S.D.: 2,14 % CV: 19,79 ------------------------------------------ Product code: AM39014RP-N (anti-CD19 PE) n: 9 Mean % positive: 10,57 S.D.: 2,06 % CV: 19,49 ------------------------------------------
Purification Affinity chromatography
Alternative Name CD19 (CD19 Antibody Abstract)
Background Progenitor B cells mature in bone marrow and subsequently appear as mature CD19+ B cells in blood. After contact with foreign antigens and the appropriate T cell help, they may further differentiate to specific antibody-producing plasma cells.The function of the CD19 Molecule is related to signal transfer and is involved in regulation of B cell proliferation. CD19 is considered to be a characteristic B cell marker and therefore commonly used in routine immunophenotyping. Detection of CD19 expressing cells is important in the diagnosis of leukemic precursor B cells (pre-B ALL), mature B cells (B ALL), and plasma cells. Distinction between subtypes of these (acute) leukemias can be performed using CD19 antibodies together with monoclonal antibodies to cytoplasmic or membrane Ig. A large number of B cell disorders can be effectively characterized by expression of CD19 and one or more additional antigens. One example is hairy cell leukemia (HCL), which shows specific expression of CD11c, CD19, CD20 and CD103. The combination CD103/CD19 is an important tool for diagnosis of HCL. Other valuable antibody combinations for distinction between different leukemias using CD19 antibodies are CD5/CD19 (e.g. Chronic Lymphatic Leukemia), CD10/CD19 (common ALL and pre-B ALL) and CD19/cyCD79a (Acute B cell leukemia). CD19 may also be expressed on follicular dendritic cells.Synonyms: B-cell marker, B-lymphocyte surface antigen B4, Differentiation antigen CD19, Leu-12
Gene ID 930
NCBI Accession NP_001171569
UniProt P15391
Research Area Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Pathways Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer 0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.
Supplier Images
 image for anti-CD19 antibody (CD19 Molecule)  (PerCP) (ABIN1105978) anti-CD19 Molecule (CD19) antibody (PerCP)
Background publications Rothe, Schmitz: "Consensus protocol for the flow cytometric immunophenotyping of hematopoietic malignancies. Working Group on Flow Cytometry and Image Analysis." in: Leukemia, Vol. 10, Issue 5, pp. 877-95, 1996 (PubMed).

Loken, Shah, Dattilio et al.: "Flow cytometric analysis of human bone marrow. II. Normal B lymphocyte development." in: Blood, Vol. 70, Issue 5, pp. 1316-24, 1987 (PubMed).