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PD-L1 antibody (CD274 Molecule)

Details for Product anti-CD274 Antibody No. ABIN1106177, Supplier: Log in to see
Antigen
  • A530045L16Rik
  • B7-H
  • B7h1
  • B7H1
  • PD-L1
  • Pdcd1l1
  • PDCD1L1
  • Pdcd1lg1
  • PDCD1LG1
  • Pdl1
  • PDL1
  • RGD1566211
Reactivity
Human
190
90
18
Host
Mouse
95
87
59
19
2
Clonality (Clone)
Monoclonal ()
Conjugate
This PD-L1 antibody is un-conjugated
23
19
19
12
6
3
3
2
2
2
1
1
Application
Flow Cytometry (FACS)
125
116
80
42
16
16
15
8
6
3
3
2
2
2
2
2
2
2
1
1
1
Supplier
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Available images

Immunogen Full-length human PD-L1 transfected L cells
Clone MIH3
Isotype IgG1
Specificity This antibody reacts with human CD274 antigen.
Purification Protein A agarose
Alternative Name CD274 / PDL1 (CD274 Antibody Abstract)
Background Programmed death ligand 1 (PD-L1, also known as CD274/B7-H1), a member of B7 family was identified by searching for molecules that share homology with the immunoglobulin V and C domains of B7-1 and B7-2 among the human cDNA expressed sequence tags in the National Center for Biotechnology Information database. PD-L1 is a ligand for programmed death 1 (PD-1) which belongs to the CD28/CTLA4 subfamily. Although in vitro study indicated that the cross-linking of PD-1 by PD-L1 leads to down-regulation of T-cell responses, some studies have shown that T cells stimulated with low levels of anti-CD3 and immobilized PD-L1-Ig were activated, proliferation and production of IFN-γ, GM-CSF and IL-10 from the T cells were enhanced.Synonyms: B7 homolog 1, B7H1, PD-L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, Programmed cell death 1 ligand 1, Programmed death ligand 1
Gene ID 29126
NCBI Accession NP_054862
UniProt Q9NZQ7
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Supplier Images
Flow Cytometry (FACS) image for anti-PD-L1 antibody (CD274 Molecule) (ABIN1106177) anti-CD274 Molecule (CD274) antibody
Background publications Yamazaki, Akiba, Iwai, Matsuda, Aoki, Tanno, Shin, Tsuchiya, Pardoll, Okumura, Azuma, Yagita: "Expression of programmed death 1 ligands by murine T cells and APC." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 10, pp. 5538-45, 2002