CD274 Molecule (CD274) antibody

Details for Product No. ABIN1106177
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Antigen
Synonyms A530045L16Rik, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, RGD1566211
Reactivity
Human
(105), (104), (43), (13), (13)
Host
Mouse
(88), (48), (35), (8)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(20), (16), (10), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application
Flow Cytometry (FACS)
(92), (67), (49), (27), (23), (20), (14), (9), (8), (4), (3), (2), (2), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States (Change)
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The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1106177
335.50 $
Plus shipping costs $45.00

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Immunogen Full-length human PD-L1 transfected L cells
Clone MIH3
Isotype IgG1
Specificity This antibody reacts with human CD274 antigen.
Purification Protein A agarose
Alternative Name CD274 / PDL1
Background Programmed death ligand 1 (PD-L1, also known as CD274/B7-H1), a member of B7 family was identified by searching for molecules that share homology with the immunoglobulin V and C domains of B7-1 and B7-2 among the human cDNA expressed sequence tags in the National Center for Biotechnology Information database. PD-L1 is a ligand for programmed death 1 (PD-1) which belongs to the CD28/CTLA4 subfamily. Although in vitro study indicated that the cross-linking of PD-1 by PD-L1 leads to down-regulation of T-cell responses, some studies have shown that T cells stimulated with low levels of anti-CD3 and immobilized PD-L1-Ig were activated, proliferation and production of IFN-γ, GM-CSF and IL-10 from the T cells were enhanced.Synonyms: B7 homolog 1, B7H1, PD-L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, Programmed cell death 1 ligand 1, Programmed death ligand 1
Gene ID 29126
NCBI Accession NP_054862
UniProt Q9NZQ7
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Supplier Images
anti-CD274 Molecule (CD274) antibody anti-CD274 Molecule (CD274) antibody
Background publications Yamazaki, Akiba, Iwai et al.: "Expression of programmed death 1 ligands by murine T cells and APC." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 10, pp. 5538-45, 2002 (PubMed).

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