MBL2 antibody (Mannose-Binding Lectin (Protein C) 2, Soluble)

Details for Product anti-MBL2 Antibody No. ABIN1108115, Supplier: Log in to see
Antigen
  • MBP-C
  • mbl2
  • MBL
  • Ab2-001
  • Ab2-011
  • L-MBP
  • MBL-C
  • COLEC1
  • HSMBPC
  • MBL2D
  • MBP
  • MBP1
  • MBPD
  • pMBP-27
  • MBL1
  • cMBl
  • collectin
  • mannose-binding lectin (protein C) 2, soluble
  • Mannose-binding protein C
  • mannose-binding lectin (protein C) 2, soluble (opsonic defect)
  • mannose-binding lectin (protein C) 2
  • MBL2
  • mbl2
  • Mbl2
Alternatives
anti-Human MBL2 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Mouse (Murine)
95
21
17
4
4
4
2
2
2
1
1
1
1
1
1
Host
Rat
67
39
8
3
Clonality (Clone)
Monoclonal ()
Conjugate
This MBL2 antibody is un-conjugated
9
6
2
2
2
2
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
108
73
47
20
14
9
8
8
5
4
3
2
1
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Immunogen Purified MBL-C
Clone 14D12
Isotype IgG2a
Cross-Reactivity (Details) Species reactivity (tested):Mouse
Purification Protein G
Alternative Name Mannan Binding Protein (MBL2 Antibody Abstract)
Background Mannose binding lectin (MBL), also called mannose- or mannan-binding protein (MBP), is a member of the group of collectins. MBL is an important pattern-recognition receptor in the innate immune system. The protein mediates innate immune responses, such as activation of the complement lectin pathway and phagocytosis, to help fight infections. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL contains a cysteine rich, a collagen like and a carbohydrate recognition domain. Binding of MBL leads to the activation of MBL-associated serine proteases (MASP's). Activated MASP-2 cleaves C4 and C2 in a similar way as C1s do for the classical pathway (CP) leading to the formation of C4b2a, cleavage of the classical pathway convertase C3, and eventually complement activation up to the formation of the membrane attack complex. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways. MBL is predominantly synthesized by hepatocytes and has been isolated from the liver or serum of several vertebrate species. Only one form of human MBL has been characterized, while two forms are found in rhesus monkeys, rabbits, rats and mice. The mouse forms are known as MBL-A and MBL-C. The MBL-C concentrations in serum are about 6-fold compared to that of MBL-A. MBL-A, but not MBL-C, was found to be an acute phase protein in casein and LPS-injection models. MBL-C exists in higher oligomeric forms than MBL-A.Synonyms: MBL, MBL2, MBP, MBP-C, MBP1, Mannan-binding protein, Mannose-binding lectin, Mannose-binding protein C
Gene ID 17195
NCBI Accession NP_034906
UniProt P41317
Research Area Complement Factors, Receptors, Serum/Plasma Proteins, Inflammation
Pathways Complement System, Positive Regulation of Immune Effector Process
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2 - 8 °C.
Supplier Images
Immunohistochemistry (IHC) image for anti-Mannose-Binding Lectin (Protein C) 2, Soluble (MBL2) antibody (ABIN1108115) anti-Mannose-Binding Lectin (Protein C) 2, Soluble (MBL2) antibody
Background publications Pumidonming, Walochnik, Dauber, Petry: "Binding to complement factors and activation of the alternative pathway by Acanthamoeba." in: Immunobiology, Vol. 216, Issue 1-2, pp. 225-33, 2010 (PubMed).

Matthijsen, de Winther, Kuipers, van der Made, Weber, Herias, Gijbels, Buurman: "Macrophage-specific expression of mannose-binding lectin controls atherosclerosis in low-density lipoprotein receptor-deficient mice." in: Circulation, Vol. 119, Issue 16, pp. 2188-95, 2009 (PubMed).

Held, Thiel, Loos, Petry: "Increased susceptibility of complement factor B/C2 double knockout mice and mannan-binding lectin knockout mice to systemic infection with Candida albicans." in: Molecular immunology, Vol. 45, Issue 15, pp. 3934-41, 2008 (PubMed).

Phaneuf, Lillie, Hayes, Turner: "Binding of mouse mannan-binding lectins to different bacterial pathogens of mice." in: Veterinary immunology and immunopathology, Vol. 118, Issue 1-2, pp. 129-33, 2007 (PubMed).

Liu, Jensen, Hansen, Petersen, Takahashi, Ezekowitz, Hansen, Jensenius, Thiel: "Characterization and quantification of mouse mannan-binding lectins (MBL-A and MBL-C) and study of acute phase responses." in: Scandinavian journal of immunology, Vol. 53, Issue 5, pp. 489-97, 2001 (PubMed).

Did you look for something else?