Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

MBP/MBL antibody

MBP/MBL Reactivity: Mouse WB, IHC (fro), EIA, IF Host: Rat Monoclonal 14D12 unconjugated
Catalog No. ABIN1108115
  • Target See all MBP/MBL Antibodies
    MBP/MBL (Mannan Binding Protein/Mannan Binding Lectin (MBP/MBL))
    Reactivity
    • 7
    • 2
    • 1
    • 1
    • 1
    Mouse
    Host
    • 5
    • 2
    Rat
    Clonality
    • 5
    • 2
    Monoclonal
    Conjugate
    • 6
    • 1
    This MBP/MBL antibody is un-conjugated
    Application
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Immunofluorescence (IF)
    Cross-Reactivity (Details)
    Species reactivity (tested):Mouse
    Purification
    Protein G
    Immunogen
    Purified MBL-C
    Clone
    14D12
    Isotype
    IgG2a
    Top Product
    Discover our top product MBP/MBL Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.1 mg/mL
    Buffer
    PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store at 2 - 8 °C.
  • Target
    MBP/MBL (Mannan Binding Protein/Mannan Binding Lectin (MBP/MBL))
    Alternative Name
    Mannan Binding Protein (MBP/MBL Products)
    Synonyms
    COLEC1 antibody, HSMBPC antibody, MBL antibody, MBL2D antibody, MBP antibody, MBP-C antibody, MBP1 antibody, MBPD antibody, pMBP-27 antibody, MBL1 antibody, cMBl antibody, collectin antibody, L-MBP antibody, MBL-C antibody, RaRF p28A antibody, mbl antibody, mannose binding lectin 2 antibody, mannose-binding lectin (protein C) 2 antibody, mannose-binding protein C-like antibody, MBL2 antibody, Mbl2 antibody, LOC100911854 antibody
    Background
    Mannose binding lectin (MBL), also called mannose- or mannan-binding protein (MBP), is a member of the group of collectins. MBL is an important pattern-recognition receptor in the innate immune system. The protein mediates innate immune responses, such as activation of the complement lectin pathway and phagocytosis, to help fight infections. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL contains a cysteine rich, a collagen like and a carbohydrate recognition domain. Binding of MBL leads to the activation of MBL-associated serine proteases (MASP's). Activated MASP-2 cleaves C4 and C2 in a similar way as C1s do for the classical pathway (CP) leading to the formation of C4b2a, cleavage of the classical pathway convertase C3, and eventually complement activation up to the formation of the membrane attack complex. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways. MBL is predominantly synthesized by hepatocytes and has been isolated from the liver or serum of several vertebrate species. Only one form of human MBL has been characterized, while two forms are found in rhesus monkeys, rabbits, rats and mice. The mouse forms are known as MBL-A and MBL-C. The MBL-C concentrations in serum are about 6-fold compared to that of MBL-A. MBL-A, but not MBL-C, was found to be an acute phase protein in casein and LPS-injection models. MBL-C exists in higher oligomeric forms than MBL-A.Synonyms: MBL, MBL2, MBP, MBP-C, MBP1, Mannan-binding protein, Mannose-binding lectin, Mannose-binding protein C
    Gene ID
    17195
    NCBI Accession
    NP_034906
    UniProt
    P41317
You are here:
Support