NFE2L3 antibody (Middle Region)

Catalog No. ABIN1108444

Product Details anti-NFE2L3 Antibody

Target: NFE2L3 (Nuclear Factor (erythroid-Derived 2)-Like 3 (NFE2L3))

Binding Specificity: Middle Region

Reactivity: Human, Cow, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NFE2L3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: NPEQTLPGTN LTGFLSPVDN HMRNLTSQDL LYDLDINIFD EINLMSLATE

Cross-Reactivity (Details): Species reactivity (expected):Mouse (92 %), Dog (92 %), Bovine (85 %), Rabbit (92 %).
Species reactivity (tested):Human.

Purification: Purified using peptide immunoaffinity column

Immunogen: The immunogen for anti-NFE2L3 antibody: synthetic peptide directed towards the middle region of human NFE2L3.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Target Details for NFE2L3

Target: NFE2L3 (Nuclear Factor (erythroid-Derived 2)-Like 3 (NFE2L3))

Alternative Name: NFE2L3 (NFE2L3 Products)

Synonyms: NRF3 antibody, Nrf3 antibody, nuclear factor, erythroid 2 like 3 antibody, nuclear factor, erythroid derived 2, like 3 antibody, nuclear factor, erythroid 2-like 3 antibody, NFE2L3 antibody, Nfe2l3 antibody

Background: NFE2L3 belongs to the bZIP family, CNC subfamily, and activates erythroid-specific, globin gene expression. It forms heterodimers with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE). NFE2L3 also called NRF3 is highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression is observed in heart, brain, lung, skeletal muscle, kidney and pancreas.Synonyms: NF-E2-related factor 3, NFE2-related factor 3, NRF3, Nuclear factor erythroid 2-related factor 3

Molecular Weight: 76 kDa (694 amino acids)

Gene ID: 9603

NCBI Accession: NP_004280