TIMP3 antibody (C-Term)

Catalog No. ABIN1109258

Product Details anti-TIMP3 Antibody

Target: TIMP3 (TIMP Metallopeptidase Inhibitor 3 (TIMP3))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIMP3 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects TIMP3 (C-term). No cross reactivity with other proteins.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Immunogen affinity purified

Immunogen: A peptide mapping at the C-terminal end of TIMP-3 of human origin .Remarks: Sequence is different to the related rat sequence by single amino acid.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3

Preservative: Sodium azide, Thimerosal (Merthiolate)

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for TIMP3

Target: TIMP3 (TIMP Metallopeptidase Inhibitor 3 (TIMP3))

Alternative Name: TIMP3 (TIMP3 Products)

Synonyms: TIMP-3 antibody, TIMP3 antibody, timp3 antibody, HSMRK222 antibody, K222 antibody, K222TA2 antibody, SFD antibody, IMP-3 antibody, timp3-A antibody, Timp-3 antibody, metalloproteinase inhibitor 3 antibody, TIMP metallopeptidase inhibitor 3 antibody, Metalloproteinase inhibitor 3 antibody, TIMP metallopeptidase inhibitor 3 L homeolog antibody, tissue inhibitor of metalloproteinase 3 antibody, CpipJ_CPIJ003282 antibody, TIMP3 antibody, timp3 antibody, Timp3 antibody, timp3.L antibody

Background: The tissue inhibitors of metalloproteinases (TIMPs) are natural inhibitors of the matrix metalloproteinases, a group of zinc-binding endopeptidases involved in the degradation of the extracellular matrix. The TIMP3 gene is expressed in many tissues, with highest expression in the placenta. TIMP3 encodes a potent angiogenesis inhibitor and is mutated in Sorsby fundus dystrophy, a macular degenerative disease with submacular choroidal neovascularization. TIMP3 gene is mapped to 22q12.1-q13.2. Mutations in TIMP3 cause the autosomal dominant disorder Sorsby's fundus dystrophy (SFD).Synonyms: Metalloproteinase inhibitor 3, Protein MIG-5, TIMP-3, Tissue inhibitor of metalloproteinases 3

Gene ID: 7078

NCBI Accession: NP_000353

UniProt: P35625