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TIMP3 antibody (C-Term)
TIMP3
Reactivity: Human, Rat, Mouse
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-TIMP3 Antibody
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Target
See all TIMP3 Antibodies
TIMP3
(TIMP Metallopeptidase Inhibitor 3 (TIMP3))
Binding Specificity
All epitopes for TIMP3 antibodies
C-Term
Reactivity
All reactivities for TIMP3 antibodies
Human, Rat, Mouse
Host
All hosts for TIMP3 antibodies
Rabbit
Clonality
All clonalities for TIMP3 antibodies
Polyclonal
Conjugate
All conjugates for TIMP3 antibodies
This TIMP3 antibody is un-conjugated
Application
All applications for TIMP3 antibodies
Western Blotting (WB)
Specificity
This antibody detects TIMP3 (C-term). No cross reactivity with other proteins.
Cross-Reactivity (Details)
Species reactivity (tested):Human, mouse, rat
Purification
Immunogen affinity purified
Immunogen
A peptide mapping at the C-terminal end of TIMP-3 of human origin .Remarks: Sequence is different to the related rat sequence by single amino acid.
Isotype
IgG
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Discover our top product TIMP3 Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Reconstitution
0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Buffer
5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3
Preservative
Sodium azide, Thimerosal (Merthiolate)
Precaution of Use
This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Target Details for TIMP3
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Target
TIMP3
(TIMP Metallopeptidase Inhibitor 3 (TIMP3))
Alternative Name
TIMP3 (TIMP3 Products )
Synonyms
TIMP-3 antibody, TIMP3 antibody, timp3 antibody, HSMRK222 antibody, K222 antibody, K222TA2 antibody, SFD antibody, IMP-3 antibody, timp3-A antibody, Timp-3 antibody, metalloproteinase inhibitor 3 antibody, TIMP metallopeptidase inhibitor 3 antibody, Metalloproteinase inhibitor 3 antibody, TIMP metallopeptidase inhibitor 3 L homeolog antibody, tissue inhibitor of metalloproteinase 3 antibody, CpipJ_CPIJ003282 antibody, TIMP3 antibody, timp3 antibody, Timp3 antibody, timp3.L antibody
Background
The tissue inhibitors of metalloproteinases (TIMPs) are natural inhibitors of the matrix metalloproteinases, a group of zinc-binding endopeptidases involved in the degradation of the extracellular matrix. The TIMP3 gene is expressed in many tissues, with highest expression in the placenta. TIMP3 encodes a potent angiogenesis inhibitor and is mutated in Sorsby fundus dystrophy, a macular degenerative disease with submacular choroidal neovascularization. TIMP3 gene is mapped to 22q12.1-q13.2. Mutations in TIMP3 cause the autosomal dominant disorder Sorsby's fundus dystrophy (SFD).Synonyms: Metalloproteinase inhibitor 3, Protein MIG-5, TIMP-3, Tissue inhibitor of metalloproteinases 3
Gene ID
7078
NCBI Accession
NP_000353
UniProt
P35625
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