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FLT1 antibody (Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor)) (C-Term)

Details for Product anti-FLT1 Antibody No. ABIN115390, Supplier: Log in to see
Antigen
  • AI323757
  • FLT
  • FLT-1
  • Flt-1
  • FLT1
  • flt1b
  • sFlt1
  • VEGFR-1
  • VEGFR1
Alternatives
anti-Human FLT1 antibody for Enzyme Immunoassay
Epitope
C-Term
31
20
13
11
9
9
8
5
5
5
5
5
5
4
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
245
74
63
12
4
2
2
2
2
2
2
1
1
1
1
1
1
1
Host
Rabbit
188
86
7
4
1
1
Clonality
Polyclonal
Conjugate
This FLT1 antibody is un-conjugated
15
10
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
171
132
55
48
36
25
21
16
12
11
11
5
2
2
1
1
1
1
Supplier
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Immunogen A synthetic peptide derived from the C-terminus of the Flt-1 precursor of human origin
Specificity This antibody reacts with a 180 kDa protein, known as Flt-1/Vascular Endothelial Growth Factor Receptor 1. Cellular localization: cytoplasmic.
Purification Purified
Alternative Name VEGFR-1 / Flt-1 (FLT1 Antibody Abstract)
Background VEGF Receptor 1 (also known as FLT) belongs to the src gene family and shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The protein acts as a receptor for VEGF, VEGFB and PGF. An alternatively spliced form of the gene produces a soluble protein (sFlt1) which binds vascular endothelial growth factor (VEGF) with high affinity. sFlt1 has a higher affinity for VEGF indicating that it may function as an inhibitor in the VEGF response. VEGF Receptor 1 is specifically expressed in most vascular endothelial cells and peripheral blood monocytes. Flt-1 is a cell membrane receptor kinase. Flk-1 has a high affinity receptor for vascular endothelial growth factor and is putatively involved in the growth of endothelial cells and angiogenesis.Synonyms: FLT, FLT1, FRT, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, VEGF Receptor 1, VEGFR1, Vascular endothelial growth factor receptor 1, Vascular permeability factor receptor
Gene ID 2321
NCBI Accession NP_001153392
UniProt P17948
Research Area Cytokines, Receptors
Pathways RTK Signaling
Application Notes Immunohistochemistry on Formalin-Fixed Paraffin Embedded Tissues: Use a dilution of1/50-1/100 in an ABC method (incubation period of 30 minutes at room temperature). Formalin fixed paraffin embedded tissue sections require high temperature antigenunmasking with 10 mM citrate buffer, pH 6.0, prior to immunostaining. Recommended Positive Control: Angiosarcoma. Also useful for Western blotting.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunohistochemistry (IHC) image for anti-FLT1 antibody (Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor)) (C-Term) (ABIN115390) Formalin fixed paraffin embedded human angiosarcoma stained with Flt-1 antibody
Background publications Sato, Kinoshita, Takino, Nakayama, Seiki: "Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2." in: FEBS letters, Vol. 393, Issue 1, pp. 101-4, 1996

Sato, Takino, Okada, Cao, Shinagawa, Yamamoto, Seiki: "A matrix metalloproteinase expressed on the surface of invasive tumour cells." in: Nature, Vol. 370, Issue 6484, pp. 61-5, 1994