CIITA
Reactivity: Human
WB, ELISA, IP
Host: Mouse
Monoclonal
unconjugated
Application Notes
Suitable for Immunoblotting (1/500), ELISA and Immunoprecipitation. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Format
Liquid
Concentration
90.0 mg/mL (by Refractometry)
Handling Advice
Avoid repeated freezing or thawing.
Storage
4 °C/-20 °C
Storage Comment
Store original vial at 2-8 °C. After reconstitution store stock solution at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.
Target
CIITA
(Class II, Major Histocompatibility Complex, Transactivator (CIITA))
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Background
The transactivator CIITA regulates basal and interferon-induced expression of Major Histocompatibility Complex class II genes. CIITA restores expression of all MHC class II gene expression in mutant cells and corrects regulatory defects of MHC class II genes. Antibodies to this transactivator are useful in the study of diseases of pathological MHC class II expression. Antigen can be obtained from Raji cell lysates. Typically levels of CIITA expression are too low to detect endogenous levels of protein expression. Transiently transfected cells are usually employed to study this transcription factor.Synonyms: MHC class II transactivator, MHC2TA