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DLL4 antibody
DLL4
Reactivity: Mouse
FACS, ICC
Host: Rat
Monoclonal
9A1-5
unconjugated
Product Details anti-DLL4 Antibody
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Target
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DLL4
(delta-Like 4 (DLL4))
Reactivity
All reactivities for DLL4 antibodies
Mouse
Host
All hosts for DLL4 antibodies
Rat
Clonality
All clonalities for DLL4 antibodies
Monoclonal
Conjugate
All conjugates for DLL4 antibodies
This DLL4 antibody is un-conjugated
Application
All applications for DLL4 antibodies
Flow Cytometry (FACS), Immunocytochemistry (ICC)
Specificity
Recognizes mouse DLL4.
Cross-Reactivity
Mouse (Murine)
Purification
Purified from concentrated hybridoma tissue culture supernatant.
Purity
>95 % (SDS-PAGE)
Immunogen
Recombinant mouse DLL4:Fc.
Clone
9A1-5
Isotype
IgG1
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
Lot specific
Buffer
In PBS containing 10 % glycerol and 0.02 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Short Term Storage: +4°C Long Term Storage: -20°C Stable for at least 1 year after receipt when stored at -20°C.
Expiry Date
12 months
References for anti-DLL4 antibody (ABIN1169261)
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Fiorini, Ferrero, Merck, Favre, Pierres, Luther, MacDonald : "Cutting edge: thymic crosstalk regulates delta-like 4 expression on cortical epithelial cells. " in: Journal of immunology (Baltimore, Md. : 1950) , Vol. 181 , Issue 12 , pp. 8199-203 , (2008 ) (PubMed ).
Target Details for DLL4
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Target
DLL4
(delta-Like 4 (DLL4))
Alternative Name
DLL4 (DLL4 Products )
Synonyms
hdelta2 antibody, Delta4 antibody, si:ch211-244p18.5 antibody, zgc:136596 antibody, delta like canonical Notch ligand 4 antibody, delta-like 4 (Drosophila) antibody, DLL4 antibody, Dll4 antibody, dll4 antibody
Background
The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, promoting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.
UniProt
Q9JI71
Pathways
Notch Signaling
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