Integrin Alpha2b antibody (FITC)

Catalog No. ABIN119841

Product Details anti-Integrin Alpha2b Antibody (FITC)

Target: Integrin Alpha2b (CD41)

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This Integrin Alpha2b antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Specificity: This antibody recognises the integrin alpha IIb subunit CD41.

Purification: Protein G affinity chromatography

Clone: MWReg30

Isotype: IgG1

Application Details

Application Notes: Flow cytometry: use 10 μL of neat - 1/10 diluted antibody to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: Clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo . We recommend the use of ABIN119839 for use in functional studies.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, pH 7.4, containing 0.09 % sodium azide and 1 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-Integrin Alpha2b antibody (FITC) (ABIN119841)

Zanzinger, Schellack, Nausch, Cerwenka: "Regulation of triggering receptor expressed on myeloid cells 1 expression on mouse inflammatory monocytes." in: Immunology, Vol. 128, Issue 2, pp. 185-95, (2009) (PubMed).

Larson, Watson: "Regulation of proplatelet formation and platelet release by integrin alpha IIb beta3." in: Blood, Vol. 108, Issue 5, pp. 1509-14, (2006) (PubMed).

Target Details for Integrin Alpha2b

Target: Integrin Alpha2b (CD41)

Alternative Name: CD41 / ITGA2B (CD41 Products)

Synonyms: AI172977 antibody, CD41 antibody, CD41B antibody, GpIIb antibody, alphaIIb antibody, BDPLT16 antibody, BDPLT2 antibody, GP2B antibody, GPIIb antibody, GT antibody, GTA antibody, HPA3 antibody, integrin alpha 2b antibody, integrin subunit alpha 2b antibody, Itga2b antibody, ITGA2B antibody

Background: CD41 is expressed on platelets and megakaryocytes and forms a heterodimer with CD61. CD41/CD61 is important for platelet adhesion and aggregation.Synonyms: GP2B, GPalpha IIb, ITGAB, Integrin alpha-IIb, Platelet membrane glycoprotein IIb

Gene ID: 16399

NCBI Accession: NP_034705

UniProt: Q9QUM0

Pathways: Integrin Complex