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Transferrin Receptor (p90, CD71) (TFRC) antibody

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Synonyms TFRC, tfr, cd71, tfr1, trfr, LOC100219280, 2610028K12Rik, AI195355, AI426448, AU015758, CD71, E430033M20Rik, Mtvr-1, Mtvr1, TFR, TFR1, TR, Trfr, p90, T9, TRFR
Rat (Rattus)
(302), (149), (44), (10), (6), (6), (6), (4), (4), (2), (2), (2)
(252), (116), (77), (9)
Clonality (Clone)
Monoclonal ()
(68), (56), (45), (18), (7), (5), (5), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunoelectron Microscopy (IEM), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
(315), (135), (91), (88), (61), (53), (37), (17), (14), (11), (9), (5), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Pubmed 6 references available
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Quantity 1 mg
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Immunogen PHA activated rat lymphocytes. Spleen cells from immunised Balb/c mice were fused with cells from the NS1 mouse myeloma cell line.
Clone OX-26
Isotype IgG2a
Purification Affinity Chromatography on Protein G.
Alternative Name CD71 / TFRC (TFRC Antibody Abstract)
Background CD71 is a homodimeric type II transmembrane protein, expressed by all proliferating cells and cells with a requirement for iron, including reticulocytes and capillary endothelium in brain. Transferrin receptor (CD71), transferrin and ferritin have been identified as specialised proteins which control the uptake, transport and storage of free iron in tissues, thereby maintaining iron homeostasis. An imbalance in iron homeostasis within the brain has been linked with the neurodegenerative diseases, Alzheimers, Parkinsons, Huntingtons and Multiple Sclerosis.Synonyms: TfR1, Transferrin receptor protein 1, p90
Gene ID 10116
UniProt Q99376
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: Use 10 μL of 1/50-1/200 diluted antibody to label 10^6 cells in 100 μL. Western Blot: This antibody detects a band of approximately 95 kDa in ConA cell lysates under Reducing conditions (MWT 195 kDA without reduction). Immunohistochemistry on Frozen Sections. Immunoprecipitation. Clone MRC OX-26 is reported as suitable for use in Electron Microscopy.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.09 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-Transferrin Receptor (p90, CD71) (TFRC) antibody (ABIN120509) Staining of rat spleen lymphocytes with MOUSE ANTI RAT CD71 (ABIN120509).
Background publications Lipardi, Ruggiano, Perrone et al.: "Differential recognition of a tyrosine-dependent signal in the basolateral and endocytic pathways of thyroid epithelial cells." in: Endocrinology, Vol. 143, Issue 4, pp. 1291-301, 2002 (PubMed).

Yefimova, Jeanny, Keller et al.: "Impaired retinal iron homeostasis associated with defective phagocytosis in Royal College of Surgeons rats." in: Investigative ophthalmology & visual science, Vol. 43, Issue 2, pp. 537-45, 2002 (PubMed).

Gambling, Danzeisen, Gair et al.: "Effect of iron deficiency on placental transfer of iron and expression of iron transport proteins in vivo and in vitro." in: The Biochemical journal, Vol. 356, Issue Pt 3, pp. 883-9, 2001 (PubMed).

Barclay: "The localization of populations of lymphocytes defined by monoclonal antibodies in rat lymphoid tissues." in: Immunology, Vol. 42, Issue 4, pp. 593-600, 1981 (PubMed).

Jefferies, Brandon, Hunt et al.: "Transferrin receptor on endothelium of brain capillaries." in: Nature, Vol. 312, Issue 5990, pp. 162-3, 1984 (PubMed).

Jefferies, Brandon, Williams et al.: "Analysis of lymphopoietic stem cells with a monoclonal antibody to the rat transferrin receptor." in: Immunology, Vol. 54, Issue 2, pp. 333-41, 1985 (PubMed).

Catalog No. ABIN120509
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