GRPR antibody (2nd Extracellular Domain)

Catalog No. ABIN122256

Product Details anti-GRPR Antibody

Target: GRPR (Gastrin-Releasing Peptide Receptor (GRPR))

Binding Specificity: 2nd Extracellular Domain

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRPR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Reacts with Human Gastrin-Releasing Peptide Receptor (GRPR, Family: GPCR, Subfamily: Bombesin), 2nd extracellular domain. GRP-R has been reported in brain, breast, colon, lung, lymph node, ovary, placenta, prostate, stomach, and uterus. It has also been shown to be expressed in several cancers, including those in breast, colon, lung, ovary, pancreas, and prostate.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Characteristics: Synonyms: GRP-R, GRPR, GRP-preferring bombesin receptor

Purification: Immunoaffinity Chromatography.

Immunogen: Synthetic peptide (2nd extracellular domain of human) - KLH conjugated. Remarks: The immunizing peptide shows 83% identity (88% homology) with Mouse andRat.

Application Details

Application Notes: Western blot (5 μg/mL). Immunocytochemistry (Use acetone as fixative). Immunohistochemistry on Paraffin Embedded Sections (4 μg/mL): Steam slides in 0.01 Msodium citrate buffer, pH 6.0 at 99-100 °C for 20 min, Remove from heat and let stand atroom temperature in buffer for 20 min.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or at -20 °C to -70 °C for longer. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.

Expiry Date: 12 months

Target Details for GRPR

Target: GRPR (Gastrin-Releasing Peptide Receptor (GRPR))

Alternative Name: Gastrin-Releasing Peptide Receptor (GRPR Products)

Synonyms: GRPR antibody, GRP-R antibody, gastrin releasing peptide receptor antibody, GRPR antibody, Grpr antibody

Background: GRPR mediates signals of cellular proliferation and it has been shown to be aberrantly expressed in several cancers such as colon, lung, ovary, pancreas and prostate. It also expressed at very high levels in normal pancreas and at lower levels in brain, breast, colon, lung, lymph node, ovary, placenta, prostate, stomach and uterus.Synonyms: GRP-R, GRP-preferring bombesin receptor, GRPR

Gene ID: 2925

UniProt: P30550