DUSP22 antibody (N-Term)

Catalog No. ABIN122298

Product Details anti-DUSP22 Antibody

Target: DUSP22 (Dual Specificity Phosphatase 22 (DUSP22))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DUSP22 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects MAP kinase phosphatase X (DUSP22 /SP-1).BLAST analysis of the peptide immunogen showed no homology with other human proteins, except DUSP15 (59 %).

Cross-Reactivity (Details): Species reactivity (expected):See 'Immunogen Remarks'Species reactivity (tested):Human

Purification: Immunoaffinity chromatography

Immunogen: Synthetic peptide - KLH conjugated

Application Details

Application Notes: Immunohistochemistry with formalin fixed paraffin embedded tissues: 2-22 μg/mL Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-80 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -70 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for DUSP22

Target: DUSP22 (Dual Specificity Phosphatase 22 (DUSP22))

Alternative Name: MAP Kinase Phosphatase X (DUSP22 Products)

Synonyms: dusp22 antibody, wu:fa11e09 antibody, zgc:92816 antibody, vhx antibody, jkap antibody, jsp1 antibody, mkpx antibody, DUSP22 antibody, ch73-170d1.1 antibody, zgc:112536 antibody, JKAP antibody, JSP1 antibody, LMWDSP2 antibody, MKPX antibody, VHX antibody, 1110028K04Rik antibody, AW212235 antibody, dual specificity phosphatase 22 antibody, dual specificity phosphatase 22a antibody, dual specificity phosphatase 22b antibody, DUSP22 antibody, dusp22a antibody, dusp22 antibody, dusp22b antibody, Dusp22 antibody

Background: MKPX, also known as JSP-1 for Jnk stimulatory phosphatase-1, belongs to the LMW-DSP subfamily of phosphatases. MKPX has been shown to have the capacity to activate the c-Jun N-terminal kinase (Jnk) signaling pathway. The activation of Jnk has been implicated in a number of important physiological processes, including embryonic morphogenesis, cell survival and apoptosis. At least two mRNA transcripts have been reported. Jnk signaling has been linked to human disease conditions, such as tumor development, cardiac hypertrophy, ischemia/reperfusion injury, diabetes, hyperglycemia-induced apoptosis, and several neurodegenerative disorders. MKPX has been shown to be widely expressed with highest expression in heart, kidney, liver, lung, pancreas and placenta. ESTs have been isolated from a diverse set of human tissues libraries, especially blood and breast. Caution: The acronym MKPX also has been used to describe Dual specificity protein phosphatase 7 (rat).Synonyms: DUSP22, Dual specificity protein phosphatase 22, JNK-stimulatory phosphatase-1, JSP1, MKPX, Mitogen-activated protein kinase phosphatase x

Gene ID: 100134291

UniProt: Q9NRW4