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TNIK antibody

TNIK Reactivity: Human IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN122435
  • Target See all TNIK Antibodies
    TNIK (TRAF2 and NCK Interacting Kinase (TNIK))
    Reactivity
    • 64
    • 53
    • 37
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 92
    • 3
    Rabbit
    Clonality
    • 92
    • 3
    Polyclonal
    Conjugate
    • 37
    • 8
    • 7
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TNIK antibody is un-conjugated
    Application
    • 41
    • 37
    • 27
    • 27
    • 18
    • 17
    • 7
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    Reacts with Traf2 and NCK-Interacting Kinase (TNIK) (Family: Protein Kinase, Subfamily: MSN)
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse, RatSpecies reactivity (tested):Human
    Purification
    Peptide immunogen affinity column
    Immunogen
    Synthetic peptide - KLH conjugated
    Top Product
    Discover our top product TNIK Primary Antibody
  • Application Notes
    Immunocytochemistry. Immunohistochemistry with formalin fixed paraffin embedded tissues: 2 μg/mL Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS, pH 7.7, containing 0.01 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-80 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -70 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    Expiry Date
    12 months
  • Target
    TNIK (TRAF2 and NCK Interacting Kinase (TNIK))
    Alternative Name
    TNIK (TNIK Products)
    Synonyms
    RGD1561817 antibody, TNIK antibody, 1500031A17Rik antibody, 4831440I19Rik antibody, AI451411 antibody, C530008O15Rik antibody, C630040K21Rik antibody, fc52d11 antibody, msn antibody, tnikl antibody, wu:fc52d11 antibody, zgc:63535 antibody, im:6898857 antibody, zgc:123033 antibody, zgc:152783 antibody, tnik antibody, TRAF2 and NCK interacting kinase antibody, TRAF2 and NCK interacting kinase a antibody, TRAF2 and NCK interacting kinase b antibody, TRAF2 and NCK interacting kinase S homeolog antibody, TNIK antibody, Tnik antibody, tnika antibody, tnikb antibody, tnik.S antibody
    Background
    TNIK is a MSN protein kinase that interacts with both TNF receptor-associated factor 2 (TRAF2) and the adapter protein NCK. The protein has been shown to activate the c-Jun N-terminal kinase pathway when overexpressed in Phoenix-A cells, and this activation is mediated solely by the C-terminal germinal center kinase homology region. TNIK has been shown to phosphorylate gelsolin, the principal intracellular and extracellular actin-severing protein, in vitro. This and evidence from mutational studies suggest that TNIK functions in the regulation of the cytoskeleton. At least eight splice isoforms have been reported. Northern analysis indicates TNIK expression in human heart, skeletal muscle, and brain, with lower levels of expression in kidney, liver, lung, and pancreas. ESTs have been isolated from human tissue libraries, including normal amnion, gallbladder, skin, and testis and cancerous bone, germ cell, nerve, and placenta.Synonyms: KIAA0551, TRAF2 and NCK-interacting protein kinase
    Gene ID
    23043
    UniProt
    Q9UKE5
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