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LRP1 antibody (Low Density Lipoprotein Receptor-Related Protein 1)

Details for Product anti-LRP1 Antibody No. ABIN125951, Supplier: Log in to see
Antigen
  • A2MR
  • APOER
  • APR
  • CD91
  • IGFBP3R
  • LRP
  • LRP1A
  • TGFBR5
  • A2mr
  • AI316852
  • Lrp
  • LRP-1
Reactivity
Hamster, Human, Mouse (Murine), Rabbit, Rat (Rattus)
150
43
27
7
5
4
4
1
1
1
Host
Mouse
79
75
2
Clonality (Clone)
Monoclonal ()
Conjugate
This LRP1 antibody is un-conjugated
14
12
10
3
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
86
62
58
44
27
26
21
15
13
6
5
3
2
1
Supplier
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Immunogen Human LRP/alpha2MR.
Clone 5A6
Isotype IgG2b
Specificity This monoclonal antibody 5A6 specifically reacts with the 85 kDa beta-chain of LRP/alpha2MR which is expressed in a restricted spectrum of cell types (for a recent review cf. Herz & Strickland). A strong immunohistochemical reaction is seen in hepatocytes, tissue macrophages, subsets of neurones and astrocytes in the central nervous system, fibroblasts, smooth muscle cells, and monocyte-derived foam cells in atherosclerotic lesions in the arterial wall. The antibody can also be used for the characterization of a subset of myelomonocytic subtypes of chronic and acute leukemia (CD 91). Cross-reacts with rabbit LDL receptor-related protein (LRP) or mouse LRP.
Purification Affinity Chromatography on Protein A.
Alternative Name CD91 / LRP1 (LRP1 Antibody Abstract)
Background Synonyms: A2MR, APOER, APR, Alpha-2-macroglobulin receptor, Apolipoprotein E receptor, Prolow-density lipoprotein receptor-related protein 1
Gene ID 4035
NCBI Accession NP_002323
UniProt Q07954
Research Area CD Antigens, Surface Receptors of Immune Cells, Receptors
Application Notes Immunofluorescence. Immunohistochemistry on Frozen Sections (Dilute 1/20). Flow Cytometry. Immunoblotting. Neutralizing effects of 5A6 have also been reported (cf. Basu et al. , 2001).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore in 1 mL dist. water
Buffer Final solution contains 0.5 % BSA in PBS buffer, pH 7.4
Precaution of Use Do Not Add Sodium Azide
Handling Advice Avoid repeated freezing and thawing. Dilute only prior to immediate use
Storage 4 °C/-20 °C
Storage Comment Store vial at 2-8 °C prior to restoration. For extended storage add glycerol to 50% and then aliquot contents and freeze at -20 °C or below. Centrifuge product if not completely clear after standing at room temperature. This antibody is stable for one month at 2-8 °C as an undiluted liquid.
Background publications Radsak, Hilf, Singh-Jasuja et al.: "The heat shock protein Gp96 binds to human neutrophils and monocytes and stimulates effector functions." in: Blood, Vol. 101, Issue 7, pp. 2810-5, 2003 (PubMed).

Herz, Strickland: "LRP: a multifunctional scavenger and signaling receptor." in: The Journal of clinical investigation, Vol. 108, Issue 6, pp. 779-84, 2001 (PubMed).

Berl, Huc, Khoury et al.: "Helical molecular programming: supramolecular double helices by dimerization of helical oligopyridine-dicarboxamide strands." in: Chemistry (Weinheim an der Bergstrasse, Germany), Vol. 7, Issue 13, pp. 2810-20, 2001 (PubMed).

Basu, Binder, Ramalingam et al.: "CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin." in: Immunity, Vol. 14, Issue 3, pp. 303-13, 2001 (PubMed).

Misra, Gawdi, Pizzo: "Ligation of low-density lipoprotein receptor-related protein with antibodies elevates intracellular calcium and inositol 1,4, 5-trisphosphate in macrophages." in: Archives of biochemistry and biophysics, Vol. 372, Issue 2, pp. 238-47, 2000 (PubMed).

Rebeck, Reiter, Strickland et al.: "Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions." in: Neuron, Vol. 11, Issue 4, pp. 575-80, 1993 (PubMed).

Strickland, Kounnas, Argraves: "LDL receptor-related protein: a multiligand receptor for lipoprotein and proteinase catabolism." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 9, Issue 10, pp. 890-8, 1995 (PubMed).

Coukos, Gåfvels, Wisel et al.: "Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and the 39-kd receptor-associated protein in human trophoblasts." in: The American journal of pathology, Vol. 144, Issue 2, pp. 383-92, 1994 (PubMed).

Strickland, Ashcom, Williams et al.: "Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor." in: The Journal of biological chemistry, Vol. 265, Issue 29, pp. 17401-4, 1990 (PubMed).

Wolf, Lopes, VandenBerg et al.: "Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain." in: The American journal of pathology, Vol. 141, Issue 1, pp. 37-42, 1992 (PubMed).