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Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) antibody

Details for Product No. ABIN125957
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Antigen
Synonyms A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5, A2mr, AI316852, Lrp, LRP-1
Reactivity
Hamster, Human, Mouse (Murine), Rabbit, Rat (Rattus)
(129), (45), (30), (13), (12), (12), (5), (1), (1)
Host
Mouse
(68), (66)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(15), (11), (6), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB), Flow Cytometry (FACS)
(69), (59), (55), (37), (30), (29), (20), (16), (15), (9), (8), (2), (1)
Pubmed 5 references available
Quantity 50 µg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN125957
456.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Human LRP/alpha2MR
Clone 8B8
Isotype IgG1
Specificity 8B8 specifically reacts with the 85 kD beta-chain of human LRP/alpha2MR which is expressed in a restricted spectrum of cell types (for a recent review cf. Herz & Strickland). A strong immunohistochemical reaction is seen in hepato-cytes, tissue macrophages, subsets of neurones and as-trocytes in the central nervous system, fibroblasts, smooth muscle cells, and monocyte-derived foam cells in athero-sclerotic lesions in the arterial wall. The antibody can also be used for the characterization of a subset of myelo-monocytic subtypes of chronic and acute leukemia (CD 91).
Purification Affinity Chromatography on Protein A.
Alternative Name CD91 / LRP1
Background Low density lipoprotein receptor-related protein (also known as low density LRP, LRP1, alpha-2-macroglobulin receptor or Apolipoprotein E receptor) is an endocytotic receptor that is involved both in endocytosis and in phagocytosis of apoptotic cells. It is required for early embryonic development, is involved in cellular lipid homeostasis, and may play a role in APP metabolism, kinase-dependent intracellular signalling, neuronal calcium signalling and neurotransmission. Low density LRP also plays a role in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha-2-macroglobulin), and is involved in the local metabolism of complexes of plasminogen activators and their endogenous ligands. Low density LPR is postulated to be one of the major players in host resistance to HIV. The precursor low density LRP molecule is cleaved post-translationally to form a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515), which remains non-covalently associated with LRP-85. Following cleavage, the intracellular domain (LPRICD) is present in both the cytoplasm and the nucleus.
Alternate names: A2MR, APOER, APR, Alpha-2-macroglobulin receptor, Apolipoprotein E receptor, Prolow- density lipoprotein receptor-related protein 1
Gene ID 4035
NCBI Accession NP_002323.2
UniProt Q07954
Research Area CD Antigens, Surface Receptors of Immune Cells, Receptors
Application Notes Immunofluorescence. Immunohistochemistry: 1/20. Flow Cytometry. Immunoblotting. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore in 1 mL dist. water.
Buffer Final Solution contains PBS buffer, pH 7.4 containing 0.5% BSA without preservatives.
Preservative Without preservative
Handling Advice This product is photosensitive and should be protected from light
Storage 4 °C
Storage Comment Prior to and following reconstitution store the antibody undiluted at 2-8°C. DO NOT FREEZE!
Expiry Date 12 months
Background publications Wolf, Lopes, VandenBerg et al.: "Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain." in: The American journal of pathology, Vol. 141, Issue 1, pp. 37-42, 1992 (PubMed).

Strickland, Ashcom, Williams et al.: "Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor." in: The Journal of biological chemistry, Vol. 265, Issue 29, pp. 17401-4, 1990 (PubMed).

Coukos, Gåfvels, Wisel et al.: "Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and the 39-kd receptor-associated protein in human trophoblasts." in: The American journal of pathology, Vol. 144, Issue 2, pp. 383-92, 1994 (PubMed).

Strickland, Kounnas, Argraves: "LDL receptor-related protein: a multiligand receptor for lipoprotein and proteinase catabolism." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 9, Issue 10, pp. 890-8, 1995 (PubMed).

Herz, Strickland: "LRP: a multifunctional scavenger and signaling receptor." in: The Journal of clinical investigation, Vol. 108, Issue 6, pp. 779-84, 2001 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN125957
456.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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