The immunoaffinity-purified antibody detects 58 kDa FLIPL on SDS-PAGE immunoblots, in samples from human, mouse and rat origins. The antibody recognizes only the FLIPL form.
Purification
Affinity purified
Immunogen
Synthetic peptide near the C-terminus of human FLIPalpha/FLIPL form.
Caspase-8 (FLICE) and -10 (FLICE2) are two pivotal members in the caspase family. Human and viral FLICE-inhibitory proteins were designated as v-FLIPs and c-FLIP, respectively. c-FLIP was cloned by several labs independently and termed Casper, I-FLICE, FLAME-1, CASH AND CLARP. c-FLIP contains two death effector domains and has sequence homology to caspase-8. c-FLIP interacts with adapter protein FADD and caspaser-8 and -10, and potently inhibits apoptosis induced by all known death receptors. Two splice variants of c-FLIP have been identified and termed FLIPL and FLIPs. The mRNA for c-FLIP is predominantly expressed in muscle and lymphoid tissue.Synonyms: CASH, CASP8 and FADD-like apoptosis regulator, CASP8AP1, CLARP, Caspase homolog, Caspase-eight-related protein, Caspase-like apoptosis regulatory protein, Cellular FLICE-like inhibitory protein, FADD-like antiapoptotic molecule 1, FLAME-1, Inhibitor of FLICE, MACH-related inducer of toxicity, MRIT, Usurpin, c-FLIP