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Caspase 6 antibody (Caspase 6, Apoptosis-Related Cysteine Peptidase) (C-Term)

Details for Product anti-CASP6 Antibody No. ABIN127030, Supplier: Log in to see
Antigen
  • casp6
  • CASP6
  • caspase-6
  • mCASP-6
  • MCH2
  • Mch2
  • mch2
  • xCaspase-6
  • zgc:112960
Alternatives
anti-Human Caspase 6 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
C-Term, active
56
38
34
17
16
15
13
13
11
6
5
5
5
4
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
270
82
78
15
3
2
1
Host
Rabbit
266
19
17
Clonality
Polyclonal
Conjugate
This Caspase 6 antibody is un-conjugated
18
17
13
10
10
10
3
3
3
3
3
3
3
3
3
Application
Western Blotting (WB)
246
146
112
58
34
28
26
14
10
6
5
1
1
Supplier
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Immunogen Synthetic peptide surrounding amino acids mapping to the Cterminus of the large fragment of human caspase-6.
Specificity The antibody detects the large subunit (18 kDa) of the active caspase-6. The antibody does not recognize other caspases.
Purification Affinity purified
Alternative Name Caspase-6 (CASP6 Antibody Abstract)
Background Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase-6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase-3, caspase-6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase-6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.Synonyms: Apoptotic protease Mch-2, CASP-6, CASP6, MCH-2, MCH2
Gene ID 839
NCBI Accession NP_001217
UniProt P55212
Research Area Apoptosis/Necrosis
Pathways Apoptosis, Caspase Cascade in Apoptosis
Application Notes Western Blot: 0.5-4 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS, pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C/-80 °C
Storage Comment Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
Background publications Cohen: "Caspases: the executioners of apoptosis." in: The Biochemical journal, Vol. 326 ( Pt 1), Issue 5693, pp. 1-16, 1997 (PubMed).

Faleiro, Kobayashi, Fearnhead, Lazebnik: "Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells." in: The EMBO journal, Vol. 16, Issue 9, pp. 2271-81, 1997 (PubMed).