STAT2 antibody (pTyr689)

Catalog No. ABIN127146

The Rabbit Polyclonal anti-STAT2 antibody (ABIN127146) specifically detects STAT2 in WB. The antibody is reactive with Human and Mouse samples.

Quick Overview for STAT2 antibody (pTyr689) (ABIN127146)

Target: STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STAT2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-STAT2 Antibody

Binding Specificity: pTyr689

Specificity: The antibody recognizes ~113 kDa phosphorylated Stat2 (Tyr689).

Purification: Immunoaffinity purified

Immunogen: Synthetic peptide corresponding to resides around amino acid 686 of mouse Stat2.

Application Details

Application Notes: Western Blot: 1-4 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 50 % glycerol, 1 % BSA, and 0.02 % thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C/-80 °C

Storage Comment: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.

Target Details for STAT2

Target: STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))

Alternative Name: STAT2

Background: Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 is activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.Synonyms: Signal transducer and activator of transcription 2, p113

Gene ID: 6773

NCBI Accession: NP_005410

UniProt: P52630

Pathways: JAK-STAT Signaling, Hepatitis C, CXCR4-mediated Signaling Events