CD11b antibody (PE)

Catalog No. ABIN135738

This anti-CD11b antibody is a Mouse Monoclonal antibody detecting CD11b in FACS. Suitable for Human.

Quick Overview for CD11b antibody (PE) (ABIN135738)

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD11b antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: ICRF44

Product Details anti-CD11b Antibody (PE)

Specificity: Human/Porcine/Rhesus/Cynomolgus/Chimpanzee/Baboon CD11b, Mr 165 kDa

Characteristics: Mouse Anti-Human CD11b-PE

Immunogen: Rheumatoid synovial cells and human monocytes

Isotype: IgG1

Application Details

Application Notes:

• Applications: FC - Quality tested , IHC-FS - Reported in literature , ICC - Reported in literature , IP - Reported in literature , WB - Reported in literature , Block - Reported in literature
• Working Dilutions: Flow Cytometry Purified (UNLB) antibody 1 g/106 cells FITC, BIOT, PE, APC, SPRD, PACBLU, AF488 and AF647 10 L/106 cells conjugates For flow cytometry, the suggested use of these reagents is in a final volume of 100 L

Comment:

Blocking Studies

Restrictions: For Research Use only

Handling

Buffer: 25 tests in 0.25 mL or 100 tests in 1.0 mL of PBS/Sodium azide and a stabilizing agent

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze!
Protect conjugated products from light.
Each reagent is stable for the period shown on the bottle label if stored as directed.

Storage: 4 °C

Storage Comment: Store at 2-8°C

Target Details for CD11b

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Alternative Name: CD11b

Background: CD11b is the 165 kDa M chain which combines with the CD18 2 integrin subunit to form the Mac-1 heterodimer. It is expressed on activated lymphocytes, monocytes, granulocytes and a subset of NK cells. CD11b/Mac-1 functions in cell-cell and cell-substrate interactions and is a ligand for C3bi, CD50 (ICAM-3), CD54 (ICAM-1) and CD102 (ICAM-2).

Pathways: Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation