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STXBP5 antibody (AA 235-380)

STXBP5 Reactivity: Human ELISA, ICC, IF (cc), IF (p), IHC (fro), IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1386695
  • Target See all STXBP5 Antibodies
    STXBP5 (Syntaxin Binding Protein 5 (Tomosyn) (STXBP5))
    Binding Specificity
    • 4
    • 1
    • 1
    • 1
    AA 235-380
    Reactivity
    • 10
    • 3
    • 2
    • 1
    Human
    Host
    • 9
    • 1
    Rabbit
    Clonality
    • 10
    Polyclonal
    Conjugate
    • 7
    • 1
    • 1
    • 1
    This STXBP5 antibody is un-conjugated
    Application
    ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Tomosyn/STXBP5
    Isotype
    IgG
    Top Product
    Discover our top product STXBP5 Primary Antibody
  • Application Notes
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    STXBP5 (Syntaxin Binding Protein 5 (Tomosyn) (STXBP5))
    Alternative Name
    Tomosyn/STXBP5 (STXBP5 Products)
    Synonyms
    LGL3 antibody, LLGL3 antibody, Nbla04300 antibody, 0710001E20Rik antibody, 4930565N16Rik antibody, AW742610 antibody, mKIAA1006 antibody, syntaxin binding protein 5 antibody, syntaxin binding protein 5 (tomosyn) antibody, STXBP5 antibody, Stxbp5 antibody
    Background

    Synonyms: FLJ30922, Lethal2 giant larvae protein homolog 3, LGL3, LLGL3, MGC141942, MGC141968, Nbla04300, STXBP5, Syntaxin binding protein 5, Syntaxin-binding protein 5, Tomosyn 1, STXB5_HUMAN.

    Background: WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. Tomosyn, also known as STXBP5 (syntaxin binding protein 5), LLGL3 or LGL3, is a 1,151 amino acid protein that localizes to the cytoplasm, as well as to the cell junction, secretory vesicles and to the peripheral membrane and contains one v-SNARE coiled-coil homology domain and 14 WD repeats. Interacting with Syntaxin 1 and Syntaxin 1B, Tomosyn functions as a regulator of neurotransmitter release and calcium-dependent exocytosis. Additionally, Tomosyn inhibits membrane fusion and may play a role in the assembly of SNARE complexes between transport vesicles and the plasma membrane. Multiple isoforms of Tomosyn exist due to alternative splicing events.

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