Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Proteoglycan 4 antibody (AA 1151-1250)

PRG4 Reactivity: Mouse, Rat, Rabbit WB, ELISA, ICC, IF (p), IHC (fro), IHC (p), IF (cc) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1387463
  • Target See all Proteoglycan 4 (PRG4) Antibodies
    Proteoglycan 4 (PRG4)
    Binding Specificity
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1151-1250
    Reactivity
    Mouse, Rat, Rabbit
    Host
    • 14
    • 2
    • 1
    Rabbit
    Clonality
    • 15
    • 2
    Polyclonal
    Conjugate
    • 12
    • 2
    • 2
    • 1
    This Proteoglycan 4 antibody is un-conjugated
    Application
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))
    Cross-Reactivity
    Mouse, Rabbit, Rat
    Predicted Reactivity
    Human,Dog,Cow
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Lubricin/SZP
    Isotype
    IgG
    Top Product
    Discover our top product PRG4 Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    Proteoglycan 4 (PRG4)
    Alternative Name
    Lubricin/SZP (PRG4 Products)
    Synonyms
    CACP antibody, HAPO antibody, JCAP antibody, MSF antibody, SZP antibody, bG174L6.2 antibody, lubricin antibody, prg4 antibody, si:dkey-97o5.3 antibody, zgc:122988 antibody, PRG4 antibody, DOL54 antibody, proteoglycan 4 antibody, proteoglycan 4b antibody, proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) antibody, PRG4 antibody, Prg4 antibody, prg4b antibody
    Background

    Synonyms: Superficial zone proteoglycan, articular superficial zone protein, bG174L6.2, CACP, camptodactyly arthropathy coxa vara pericarditis syndrome gene, FLJ32635, HAPO, Jacobs camptodactyly-arthropathy-pericarditis syndrome gene, JCAP, megakaryocyte stimulating factor, MSF, PRG 4, PRG4, proteoglycan 4, Proteoglycan4, Superficial zone proteoglycan, SZP.

    Background: Lubricin, also designated proteoglycan-4 or megakaryocyte stimulating factor, is important for boundary lubrication within articulating joints. It is a disulfide-linked homodimer (between Cysteine 1146 and Cysteine 1403) that is essential for protein cleavage. Lubricin inhibits synovial cell adhesion to the cartilage surface, but also prevents the deposition of proteins from synovial fluid onto cartilage. Lubricin is highly expressed in cartilage, liver and synovial tissue. Defects in the gene encoding for lubricin can cause Jakobs syndrome, also designated camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP). CACP is an autosomal recessive disorder characterized by joint failure associated with noninflammatory synoviocyte hyperplasia and subinitimal fibrosis of the synovial capsule. Lubricin undergoes different levels of glycosylation and may be detected at varying molecular weights.

    Gene ID
    10216
    UniProt
    Q92954
You are here:
Support