MPL antibody (AA 401-500) (FITC)
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- Target See all MPL Antibodies
- MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
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Binding Specificity
- AA 401-500
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MPL antibody is conjugated to FITC
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Application
- Western Blotting (WB), Flow Cytometry (FACS)
- Cross-Reactivity
- Human, Mouse
- Predicted Reactivity
- Rat,Rabbit
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human TPOR
- Isotype
- IgG
- Top Product
- Discover our top product MPL Primary Antibody
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- Application Notes
- FCM 1:20-100
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
- Alternative Name
- TPOR (MPL Products)
- Synonyms
- C-MPL antibody, CD110 antibody, MPLV antibody, THCYT2 antibody, TPOR antibody, TPO-R antibody, c-mpl antibody, c-mpl-I antibody, c-mpl-II antibody, hlb219 antibody, MPL antibody, mpll antibody, tpor antibody, tpor.b antibody, MPL proto-oncogene, thrombopoietin receptor antibody, myeloproliferative leukemia virus oncogene antibody, MPL antibody, Mpl antibody, mpl antibody
- Background
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Synonyms: C MPL, C-MPL, CMPL, CD110, CD 110, MPL, MPLV, Myeloprolerative leukemia protein, Myeloprolerative leukemia virus oncogene, Proto-oncogene c-Mpl, THCYT2, Thrombopoietin receptor, TPO R, TPO-R, TPOR, TPOR_HUMAN.
Background: Thrombopoietin (TPO or THPO), also known as c-Mpl ligand (c-Mpl L), is a cytokine that plays a central role in megakaryopoiesis by influencing the development and maturation of megakaryocytes and platelet production from hematopoietic stem cells. TPO exerts its biological effects through the TPO receptor, c-Mpl. c-Mpl is a member of the cytokine receptor superfamily. Expression of c-Mpl is restricted to hematopoietic tissues and cells, such as bone marrow, spleen, fetal liver and CD34+ cells. Stimulation of c-Mpl with TPO results in the activation of the Janus tyrosine kinase family members, Tyk 2 and JAK2, which in turn phosphorylate Stat5 and Stat3, causing their nuclear translocation and the transcription of Stat responsive genes. Muta-tions in c-Mpl have been implicated as the cause of certain human disorders, including congenital amegakaryocytic thrombocytopenia (CAMT) and thrombocytopenia with absent radii (TAR) syndrome.
- Pathways
- JAK-STAT Signaling
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