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CD93 antibody (CD93 Molecule)

Details for Product anti-CD93 Antibody No. ABIN1449221, Supplier: Log in to see
Antigen
  • 6030404G09Rik
  • AA4.1
  • AA145088
  • AW555904
  • C1qR(P)
  • C1QR1
  • C1qr1
  • C1qRP
  • C1qrp
  • C1qRp
  • CDw93
  • dJ737E23.1
  • ECSM3
  • Ly68
  • MXRA4
Reactivity
Human
49
37
17
10
Host
Mouse
30
22
21
Clonality (Clone)
Monoclonal ()
Conjugate
This CD93 antibody is un-conjugated
9
7
5
4
3
3
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunoprecipitation (IP)
36
25
18
11
11
7
5
5
4
4
3
3
2
2
2
1
Supplier
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Immunogen LPS-stimulated U937
Clone MNI-11
Isotype IgG1
Specificity This antibody reacts with CD93 antigen. mNI-11 has been reported to induce intercellular adhesion of LPS-stimulated monocyte (U937) cells as well as inducing the adhesion of these cells to an endothelial (HUVEC) cell layer and rapid spread formation in HUVECs.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein A agarose
Alternative Name CD93 / C1QR1 (CD93 Antibody Abstract)
Background CD93, also known as C1qRp, is a 100-125 kDa type I membrane protein that is a receptor for the complement protein C1q. CD93 has also been shown to act as a receptor for mannose-binding lectin and surfactant protein A. CD93 is expressed on the surface of monocytes, granulocytes, and endothelial cells, and expression is increased by TNF-α or GM-CSF. CD93 is involved in ligand-mediated enhancement of phagocytosis and intercellular adhesion.Synonyms: C1q receptor, C1q/MBL/SPA receptor, CDw93, Complement component 1 q subcomponent receptor 1, Complement component C1q receptor, MBL receptor, MXRA4, Matrix-remodeling-associated protein 4, SPA receptor
Gene ID 22918
NCBI Accession NP_036204
UniProt Q9NPY3
Research Area CD Antigens
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Upon receipt, store (in aliqouts) at -20 °C.
Supplier Images
Immunohistochemistry (IHC) image for anti-CD93 antibody (CD93 Molecule) (ABIN1449221) anti-CD93 Molecule (CD93) antibody
Flow Cytometry (FACS) image for anti-CD93 antibody (CD93 Molecule) (ABIN1449221) anti-CD93 Molecule (CD93) antibody (Image 2)
Flow Cytometry (FACS) image for anti-CD93 antibody (CD93 Molecule) (ABIN1449221) anti-CD93 Molecule (CD93) antibody (Image 3)
Western Blotting (WB) image for anti-CD93 antibody (CD93 Molecule) (ABIN1449221) anti-CD93 Molecule (CD93) antibody (Image 4)
Background publications Ikewaki, Tamauchi, Inoko: "Decrease in CD93 (C1qRp) expression in a human monocyte-like cell line (U937) treated with various apoptosis-inducing chemical substances." in: Microbiology and immunology, Vol. 51, Issue 12, pp. 1189-200, 2007 (PubMed).

Ikewaki, Kulski, Inoko: "Regulation of CD93 cell surface expression by protein kinase C isoenzymes." in: Microbiology and immunology, Vol. 50, Issue 2, pp. 93-103, 2006 (PubMed).

McGreal, Ikewaki, Akatsu, Morgan, Gasque: "Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 10, pp. 5222-32, 2002 (PubMed).

Ikewaki, Inoko: "Development and characterization of a novel monoclonal antibody (mNI-11) that induces cell adhesion of the LPS-stimulated human monocyte-like cell line U937." in: Journal of leukocyte biology, Vol. 59, Issue 5, pp. 697-708, 1996 (PubMed).