MDM4-binding Protein antibody (pSer367)

Catalog No. ABIN1449256

Product Details anti-MDM4-binding Protein Antibody

Target: MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

Binding Specificity: pSer367

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This MDM4-binding Protein antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody specifically recognizes MdmX protein phosphorylated at Ser367.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse

Clone: #15

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store (in aliqouts) at -20 °C.

Target Details for MDM4-binding Protein

Target: MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

Alternative Name: MDM4 (MDM4 Products)

Synonyms: mdmx antibody, HDMX antibody, MDMX antibody, MRP1 antibody, wu:fa09h09 antibody, wu:fi33d10 antibody, 4933417N07Rik antibody, AA414968 antibody, AL023055 antibody, AU018793 antibody, AU021806 antibody, C85810 antibody, Mdmx antibody, MDM4, p53 regulator S homeolog antibody, MDM4, p53 regulator antibody, transformed mouse 3T3 cell double minute 4 antibody, mdm4.S antibody, MDM4 antibody, Mdm4 antibody, mdm4 antibody

Background: MdmX (Mdm4, HdmX) inhibits p53-and p73-dependent cell cycle arrest and apoptosis by binding to the transcription activation domains of these proteins. MdmX consists of 490 amino acids with the molecular weight of 54,864 and contains a RIING-finger domain and a nuclear transport signal. It is known that the protein migrates aberrantly in SDS-PAGE at the position of an 80 kDa protein. MdmX is phosphorylated at Ser367 by Chk2 kinase downstream of ATM in response to DNA damage, and as the result, it binds to 14-3-3 and is transported into nucleus where it is degraded by Mdm2. This process activates the p53 functions (Ref 1, 2, 3).Synonyms: Double minute 4 protein, MDM-4, MDMX, Mdm2-like p53-binding protein, p53-binding protein Mdm4

Gene ID: 4194

NCBI Accession: NP_002384

UniProt: O15151

Pathways: Cell Division Cycle