Autophagy Related 4D, Cysteine Peptidase (ATG4D) (AA 49-79), (N-Term) antibody

Details for Product No. ABIN1449592, Supplier: Log in to see
Antigen
  • APG4-D
  • APG4D
  • AUTL4
  • 9830134P12Rik
  • Apg4d
  • Atg4dl
  • Autl4
  • apg4d
  • autophagy related 4D, cysteine peptidase
  • ATG4 autophagy related 4 homolog D (S. cerevisiae)
  • ATG4D
  • Atg4d
  • atg4d
Epitope
AA 49-79, N-Term
32
27
18
15
15
14
13
12
7
3
3
2
2
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
151
76
44
5
4
2
2
2
1
Host
Rabbit
120
16
16
2
Clonality
Polyclonal
Conjugate
Un-conjugated
8
8
8
6
6
6
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
114
53
52
39
26
23
18
1
1
Options
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Immunogen KLH conjugated synthetic peptide between 49-79 amino acids from the N-terminal region of Human ATG4D
Isotype Ig
Purification Saturated Ammonium Sulfate precipitation followed by dialysis against PBS
Alternative Name APG4D / ATG4D (ATG4D Antibody Abstract)
Background Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases.Synonyms: AUT-like 4 cysteine endopeptidase, AUTL4, Autophagin-4, Autophagy-related cysteine endopeptidase 4, Autophagy-related protein 4 homolog D, Cysteine protease ATG4D
Molecular Weight 52922 Da
Gene ID 84971
NCBI Accession NP_116274
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Autophagy Related 4D, Cysteine Peptidase (ATG4D) (AA 49-79), (N-Term) antibody (ABIN1449592) Formalin Fixed, Paraffin Embedded Human skeletal muscle stained with ATG4D Antibody (...
Western Blotting (WB) image for anti-Autophagy Related 4D, Cysteine Peptidase (ATG4D) (AA 49-79), (N-Term) antibody (ABIN1449592) Western blot analysis in mouse liver tissue lysates using ATG4D Antibody (N-term) Cat...
Background publications Betin, Lane: "Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis." in: Journal of cell science, Vol. 122, Issue Pt 14, pp. 2554-66, 2009 (PubMed).

Lamesch, Li, Milstein, Fan, Hao, Szabo, Hu, Venkatesan, Bethel, Martin, Rogers, Lawlor, McLaren, Dricot, Borick, Cusick, Vandenhaute, Dunham, Hill, Vidal: "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes." in: Genomics, Vol. 89, Issue 3, pp. 307-15, 2007 (PubMed).

Mariño, Uría, Puente, Quesada, Bordallo, López-Otín: "Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy." in: The Journal of biological chemistry, Vol. 278, Issue 6, pp. 3671-8, 2003 (PubMed).