ANKLE2 antibody (Middle Region)

Catalog No. ABIN1449856

Product Details anti-ANKLE2 Antibody

Target: ANKLE2 (Ankyrin Repeat and LEM Domain Containing 2 (ANKLE2))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANKLE2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: CYSPSDRQSW PSPAVKGRFK SQLPDLSGPH SYSPGRNSVA GSNPAKPGLG

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Purified using peptide immunoaffinity column

Immunogen: Synthetic peptide directed towards the middle region of human KIAA0692

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Target Details for ANKLE2

Target: ANKLE2 (Ankyrin Repeat and LEM Domain Containing 2 (ANKLE2))

Alternative Name: ANKLE2 / KIAA0692 (ANKLE2 Products)

Synonyms: KIAA0692 antibody, LEMD7 antibody, Lem4 antibody, 1110001J12Rik antibody, AI661024 antibody, D5Ertd585e antibody, RGD1310191 antibody, ankyrin repeat and LEM domain containing 2 antibody, ANKLE2 antibody, Ankle2 antibody

Background: ANKLE2 or KIAA0692 is a single-pass membrane protein. It contains 1 ANK repeat and 1 LEM domain. It contains 1 RING-type zinc finger. It is involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. ANKLE2 coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex.Synonyms: Ankyrin repeat and LEM domain-containing protein 2

Gene ID: 23141

NCBI Accession: NP_055929