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CHD7 antibody (Chromodomain Helicase DNA Binding Protein 7) (N-Term)

Details for Product anti-CHD7 Antibody No. ABIN1450043, Supplier: Log in to see
Antigen
  • A730019I05Rik
  • CHD7
  • Cycn
  • Cyn
  • Dz
  • Edy
  • fd19h06
  • Flo
  • GENA 47
  • Gena 52
  • GENA 60
  • HH5
  • IS3
  • KAL5
  • Lda
  • metis
  • Mt
  • Obt
  • si:ch211-197o6.2
  • Todo
  • WBE1
  • Whi
  • wu:cegs2051
  • wu:fb37f10
  • wu:fb39h04
  • wu:fd19h06
Epitope
N-Term
18
13
13
1
1
1
Reactivity
Human, Mouse (Murine)
39
21
5
1
1
1
1
1
Host
Rabbit
23
17
1
Clonality
Polyclonal
Conjugate
This CHD7 antibody is un-conjugated
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
26
20
17
16
14
14
2
1
Supplier
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Immunogen CHD7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CHD7
Isotype IgG
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse.
Purification Affinity chromatography purified via peptide column
Alternative Name CHD7 (CHD7 Antibody Abstract)
Background CHD proteins belong to a superfamily of proteins of ATP-dependent chromatin remodeling enzymes that have a unique combination of functional domains, including two N-terminal chromodomains, a SNF2-like ATPase/helicase domain and a DNA-binding domain. These proteins are thought to play a role in early embryonic development by affecting chromatin structure and gene expression. Mutations in one member of this family, CHD7, result in CHARGE syndrome. It colocalizes with embryonic stem (ES) cell master regulators OCT4/POU5F1, SOX2, and NANOG and is thought to modulate ES-specific gene transcription. Together with SOX2, CHD7 has been suggested to also regulate several human disease genes.Synonyms: ATP-dependent helicase CHD7, CHD-7, Chromodomain-helicase-DNA-binding protein 7, KIAA1416
Gene ID 55636
UniProt Q9P2D1
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-CHD7 antibody (Chromodomain Helicase DNA Binding Protein 7) (N-Term) (ABIN1450043) Immunohistochemistry of CHD7 in mouse brain tissue with CHD7 antibody at 5 ug/mL.
Western Blotting (WB) image for anti-CHD7 antibody (Chromodomain Helicase DNA Binding Protein 7) (N-Term) (ABIN1450043) Western blot analysis of CHD7 in SK-N-SH cell lysate with CHD7 antibody at (A) 1 and ...
Background publications Schnetz, Handoko, Akhtar-Zaidi, Bartels, Pereira, Fisher, Adams, Flicek, Crawford, Laframboise, Tesar, Wei, Scacheri: "CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001023, 2010 (PubMed).

Vissers, van Ravenswaaij, Admiraal, Hurst, de Vries, Janssen, van der Vliet, Huys, de Jong, Hamel, Schoenmakers, Brunner, Veltman, van Kessel: "Mutations in a new member of the chromodomain gene family cause CHARGE syndrome." in: Nature genetics, Vol. 36, Issue 9, pp. 955-7, 2004 (PubMed).

Cavalli, Paro: "Chromo-domain proteins: linking chromatin structure to epigenetic regulation." in: Current opinion in cell biology, Vol. 10, Issue 3, pp. 354-60, 1998 (PubMed).

Woodage, Basrai, Baxevanis, Hieter, Collins: "Characterization of the CHD family of proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 21, pp. 11472-7, 1997 (PubMed).