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UHRF1 Binding Protein 1-Like (UHRF1BP1L) (Middle Region) antibody

Details for Product No. ABIN1450050, Supplier: Log in to see
Antigen
  • MGC80013
  • UHRF1BP1L
  • si:dkeyp-90a8.1
  • 2010319N22Rik
  • 4930506D01Rik
  • AA589495
  • C80672
  • E030041M21Rik
  • mKIAA0701
  • SHIP164
Epitope
Middle Region
16
11
7
3
2
2
2
Reactivity
Human, Mouse (Murine)
24
2
Host
Rabbit
21
3
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
22
16
1
Supplier
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Immunogen 17 amino acid synthetic peptide near the center of Human UHRF1BP1L
Isotype IgG
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse.
Purification Affinity chromatography purified via peptide column
Alternative Name UHRF1BP1L
Background The Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1-like (UHRF1BP1L) is closely related to UHRF1BP1, also known as ICBP90, a transcription and cell cycle regulator that specifically binds to the histone H3 N-terminal tail. While little is known of UHRF1BP1L, UHRF1BP1 is required for proper heterochromatin formation in mammalian cells. Furthermore, UHRF1BP1 is thought to be a pivotal target for the ERK1/2 signaling pathway to control the proliferation of Jurkat T cells, suggesting that UHRF1BP1L may also be involved in chromatin regulation and cell proliferation.Synonyms: KIAA0701, UHRF1-binding protein 1-like
Gene ID 23074
NCBI Accession NP_055869
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-UHRF1 Binding Protein 1-Like (UHRF1BP1L) (Middle Region) antibody (ABIN1450050) Immunohistochemistry of UHRF1BP1L in human kidney tissue with UHRF1BP1L antibody at 2...
Western Blotting (WB) image for anti-UHRF1 Binding Protein 1-Like (UHRF1BP1L) (Middle Region) antibody (ABIN1450050) Western blot analysis of UHRF1BP1L in mouse brain tissue lysate with UHRF1BP1L antibo...
Product cited in: Karagianni, Amazit, Qin et al.: "ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation." in: Molecular and cellular biology, Vol. 28, Issue 2, pp. 705-17, 2008 (PubMed).

Background publications Fang, Xing, Bronner et al.: "ICBP90 mediates the ERK1/2 signaling to regulate the proliferation of Jurkat T cells." in: Cellular immunology, Vol. 257, Issue 1-2, pp. 80-7, 2009 (PubMed).

Unoki, Nishidate, Nakamura: "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain." in: Oncogene, Vol. 23, Issue 46, pp. 7601-10, 2004 (PubMed).

Hopfner, Mousli, Jeltsch et al.: "ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression." in: Cancer research, Vol. 60, Issue 1, pp. 121-8, 2000 (PubMed).