Aggrecan antibody
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- Target See all Aggrecan (ACAN) Antibodies
- Aggrecan (ACAN)
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Reactivity
- Human, Cow
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Aggrecan antibody is un-conjugated
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Application
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)
- Cross-Reactivity (Details)
- Species reactivity (tested):Human and Bovine.
- Purification
- Prepared by Affinity Chromatography on Protein G from Tissue Culture Supernatant
- Immunogen
- Purified Human articular cartilage Aggrecan. Remarks: Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
- Clone
- HAG7D4 (7D4)
- Isotype
- IgG1
- Top Product
- Discover our top product ACAN Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS, 0.09 % Sodium Azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the lyophilized product at 2-8 °C. Following reconstitution store (in aliquots) at -20 °C.
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Gelatin-based haemostyptic Spongostan as a possible three-dimensional scaffold for a chondrocyte matrix?: an experimental study with bovine chondrocytes." in: The Journal of bone and joint surgery. British volume, Vol. 91, Issue 3, pp. 409-16, (2009) (PubMed).
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Gelatin-based haemostyptic Spongostan as a possible three-dimensional scaffold for a chondrocyte matrix?: an experimental study with bovine chondrocytes." in: The Journal of bone and joint surgery. British volume, Vol. 91, Issue 3, pp. 409-16, (2009) (PubMed).
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- Target
- Aggrecan (ACAN)
- Alternative Name
- Aggrecan (ACAN Products)
- Synonyms
- AGC1 antibody, AGCAN antibody, CSPG1 antibody, CSPGCP antibody, MSK16 antibody, SEDK antibody, Agc antibody, Agc1 antibody, Cspg1 antibody, b2b183Clo antibody, cmd antibody, aggrecan antibody, aggrecan core protein antibody, ACAN antibody, Acan antibody, LOC100380783 antibody, AGC antibody
- Background
- Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3. Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS.Synonyms: ACAN, AGC1, CSPG1, Cartilage-specific proteoglycan core protein, Chondroitin sulfate proteoglycan core protein 1, MSK16
- Gene ID
- 176, 9606
- UniProt
- P16112
- Pathways
- Glycosaminoglycan Metabolic Process, Dicarboxylic Acid Transport
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