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USP8 antibody (C-Term)

USP8 Reactivity: Human WB Host: Mouse Monoclonal 460CT35-1-6 unconjugated
Catalog No. ABIN1536612
  • Target See all USP8 Antibodies
    USP8 (Ubiquitin Specific Peptidase 8 (USP8))
    Binding Specificity
    • 7
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30, C-Term
    Reactivity
    • 35
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 33
    • 1
    • 1
    Mouse
    Clonality
    • 34
    • 1
    Monoclonal
    Conjugate
    • 25
    • 2
    • 2
    • 2
    • 2
    • 2
    This USP8 antibody is un-conjugated
    Application
    • 31
    • 15
    • 13
    • 6
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Predicted Reactivity
    M
    Purification
    Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
    Immunogen
    This USP8 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the C-terminal region of human USP8.
    Clone
    460CT35-1-6
    Isotype
    IgG1
    Top Product
    Discover our top product USP8 Primary Antibody
  • Application Notes
    WB: 1:500~4000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    USP8 Antibody (C-term C1072)(Ascites) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
    Expiry Date
    6 months
  • Target
    USP8 (Ubiquitin Specific Peptidase 8 (USP8))
    Alternative Name
    USP8 (USP8 Products)
    Synonyms
    HumORF8 antibody, UBPY antibody, AI574262 antibody, AW557536 antibody, Ubpy antibody, mKIAA0055 antibody, ubiquitin carboxyl-terminal hydrolase 8 antibody, ubiquitin specific peptidase 8 antibody, LOC9310109 antibody, MGYG_00369 antibody, USP8 antibody, Usp8 antibody
    Background
    Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules.
    Molecular Weight
    127523
    Gene ID
    9101
    NCBI Accession
    NP_001122082, NP_001122083, NP_005145
    UniProt
    P40818
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