CRYGA antibody (N-Term)

Catalog No. ABIN1544446

Product Details anti-CRYGA Antibody

Target: CRYGA (Crystallin, gamma A (CRYGA))

Binding Specificity: N-Term

Reactivity: Human, Cow, Dog, Guinea Pig, Horse, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRYGA antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SIRVDSGCWM LYERPNYQGH QYFLRRGKYP DYQHWMGLSD SVQSCRIIPH

Predicted Reactivity: Cow: 79%, Dog: 79%, Guinea Pig: 79%, Horse: 79%, Human: 100%, Mouse: 79%, Rabbit: 79%, Rat: 79%, Zebrafish: 82%

Characteristics: This is a rabbit polyclonal antibody against CRYGA. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human CRYGA

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 174 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CRYGA

Target: CRYGA (Crystallin, gamma A (CRYGA))

Alternative Name: CRYGA (CRYGA Products)

Synonyms: CRY-g-A antibody, CRYG1 antibody, CRYG5 antibody, Cryg-4 antibody, DGcry-4 antibody, cryg1 antibody, cryg5 antibody, MGC85425 antibody, CRYGA antibody, crystallin gamma A antibody, crystallin, gamma A antibody, crystallin gamma A L homeolog antibody, gamma-crystallin A antibody, CRYGA antibody, Cryga antibody, cryga.L antibody, LOC100630282 antibody, LOC100355936 antibody

Background: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families, beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.
Alias Symbols: CRY-g-A, CRYG1, CRYG5
Protein Interaction Partner: TRAF1,
Protein Size: 174

Molecular Weight: 21 kDa

Gene ID: 1418

NCBI Accession: NM_014617, NP_055432

UniProt: P11844