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ENPP3 antibody (FITC)

ENPP3 Reactivity: Human FACS Host: Mouse Monoclonal NP4D6 FITC
Catalog No. ABIN1690738
  • Target See all ENPP3 Antibodies
    ENPP3 (Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3))
    Reactivity
    • 66
    • 34
    • 18
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Human
    Host
    • 52
    • 14
    Mouse
    Clonality
    • 53
    • 13
    Monoclonal
    Conjugate
    • 23
    • 6
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ENPP3 antibody is conjugated to FITC
    Application
    • 28
    • 25
    • 25
    • 13
    • 13
    • 7
    • 6
    • 6
    • 3
    • 3
    • 2
    • 1
    Flow Cytometry (FACS)
    Specificity
    The mouse monoclonal antibody NP4D6 reacts with an extracellular epitope of CD203c, a transmembrane ectoenzyme expressed on basophils and mast cells, and overexpressed upon their activation.
    Cross-Reactivity (Details)
    Human
    Purification
    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogen
    HEK-293 cells transfected with human CD203c
    Clone
    NP4D6
    Isotype
    IgG1
    Top Product
    Discover our top product ENPP3 Primary Antibody
  • Application Notes
    Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests. Extracellular and intracellular staining.
    Comment

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Reconstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do not freeze.
    Avoid prolonged exposure to light.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Heneberg, Riegerová, Kučera: "Pimecrolimus Is a Potent Inhibitor of Allergic Reactions to Hymenopteran Venom Extracts and Birch Pollen Allergen In Vitro." in: PLoS ONE, Vol. 10, Issue 11, pp. e0142953, (2015) (PubMed).

    Platz, Binder, Marxer, Lischka, Valent, Bühring: "Hymenoptera-venom-induced upregulation of the basophil activation marker ecto-nucleotide pyrophosphatase/phosphodiesterase 3 in sensitized individuals." in: International archives of allergy and immunology, Vol. 126, Issue 4, pp. 335-42, (2002) (PubMed).

    Bühring, Seiffert, Giesert, Marxer, Kanz, Valent, Sano: "The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3." in: Blood, Vol. 97, Issue 10, pp. 3303-5, (2001) (PubMed).

    Bühring, Simmons, Pudney, Müller, Jarrossay, van Agthoven, Willheim, Brugger, Valent, Kanz: "The monoclonal antibody 97A6 defines a novel surface antigen expressed on human basophils and their multipotent and unipotent progenitors." in: Blood, Vol. 94, Issue 7, pp. 2343-56, (1999) (PubMed).

  • Target
    ENPP3 (Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3))
    Alternative Name
    CD203c (ENPP3 Products)
    Synonyms
    B10 antibody, CD203c antibody, NPP3 antibody, PD-IBETA antibody, PDNP3 antibody, Npp3 antibody, RB13-6 antibody, AI876438 antibody, ENPP3 antibody, ectonucleotide pyrophosphatase/phosphodiesterase 3 antibody, ectonucleotide pyrophosphatase/phosphodiesterase 3 L homeolog antibody, ENPP3 antibody, Enpp3 antibody, enpp3 antibody, enpp3.L antibody
    Background
    Ectonucleotide pyrophosphatase/phosphodiesterase 3,CD203c, also known as ENPP-3, is integral membrane ectoenzyme (ectonucleotide pyrophosphatase/phosphodiesterase 3), that hydrolyses nucleotide triphosphates and thus modulates purinergic signaling. CD203c is expressed mainly on activated basophils and mast cells. CD203c is upregulated in response to IgE-receptor cross-linking and is overexpressed on neoplastic mast cells in patients with systemic mastocytosis. Measurement of its induced enhancement on the plasma membrane is useful for diagnostics of allergies.,ENPP3, B10, PDNP3, PD-IBETA
    Gene ID
    5169
    UniProt
    O14638
    Pathways
    Regulation of Muscle Cell Differentiation, Negative Regulation of Transporter Activity
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