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ERBB3 antibody (pTyr1276) (Biotin)

ERBB3 Reactivity: Rat, Dog ELISA, IHC (p), IHC (fro) Host: Rabbit Polyclonal Biotin
Catalog No. ABIN1700150
  • Target See all ERBB3 Antibodies
    ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
    Binding Specificity
    • 29
    • 26
    • 21
    • 15
    • 14
    • 12
    • 9
    • 8
    • 7
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr1276
    Reactivity
    • 183
    • 127
    • 113
    • 16
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Rat, Dog
    Host
    • 188
    • 28
    • 1
    • 1
    Rabbit
    Clonality
    • 185
    • 33
    Polyclonal
    Conjugate
    • 114
    • 12
    • 10
    • 10
    • 10
    • 10
    • 10
    • 10
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    This ERBB3 antibody is conjugated to Biotin
    Application
    • 103
    • 66
    • 53
    • 53
    • 50
    • 31
    • 29
    • 20
    • 19
    • 15
    • 8
    • 3
    • 3
    • 3
    • 2
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Dog, Rat
    Predicted Reactivity
    Human,Cow,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic phosphopeptide derived from human HER3 around the phosphorylation site of Tyr1276
    Isotype
    IgG
    Top Product
    Discover our top product ERBB3 Primary Antibody
  • Application Notes
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
    Alternative Name
    HER3 (ERBB3 Products)
    Synonyms
    ErbB-3 antibody, HER3 antibody, LCCS2 antibody, MDA-BF-1 antibody, c-erbB-3 antibody, c-erbB3 antibody, erbB3-S antibody, p180-ErbB3 antibody, p45-sErbB3 antibody, p85-sErbB3 antibody, ERBB3 antibody, C76256 antibody, Erbb-3 antibody, Erbb3r antibody, Her3 antibody, nuc-ErbB3 antibody, erb-b2 receptor tyrosine kinase 3 antibody, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody, ERBB3 antibody, Erbb3 antibody
    Background

    Synonyms: Her3/ErbB3Tyr1276, p-HRE3 Tyr1276, ErbB 3 phospho Y1276, ERBB3, c erbB 3, c erbB3, ERBB3 protein, erbB3 S, Glial growth factor receptor, HER 3, HER3, LCCS2, MDA BF 1, MGC88033, p180 ErbB3, p45 sErbB3, p85 sErbB3, proto-oncogene-like protein c ErbB 3, proto-oncogene-like protein c ErbB3, receptor tyrosine protein kinase ERB3, Receptor tyrosine protein kinase erbB 3, Receptor tyrosine protein kinase erbB3, Tyrosine kinase type cell surface receptor HER3, ERBB3_HUMAN.

    Background: ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. Isoform 2 lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized. Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2), also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord.

    Gene ID
    2065
    Pathways
    RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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