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APP antibody (AA 85-99, AA 737-751)
APP
Reactivity: Human, Mouse, Rat
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-APP Antibody
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Target
See all APP Antibodies
APP
(Amyloid beta (A4) Precursor Protein (APP))
Binding Specificity
All epitopes for APP antibodies
AA 85-99, AA 737-751
Reactivity
All reactivities for APP antibodies
Human, Mouse, Rat
Host
All hosts for APP antibodies
Rabbit
Clonality
All clonalities for APP antibodies
Polyclonal
Conjugate
All conjugates for APP antibodies
This APP antibody is un-conjugated
Application
All applications for APP antibodies
Western Blotting (WB)
Specificity
Reacts with the human, mouse, and rat APP and the C99 fragment.
Purification
Purified
Immunogen
Peptide corresponding to aa 737-751 of human amyloid protein precursor (APP) or aa 85-99 of the C99 fragment generated by beta- secretase cleavage. The sequences are identical to those of monkey, mouse, rat, chicken, and a variety of other species
Isotype
IgG
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Discover our top product APP Primary Antibody
Alternatives
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Application Details
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Application Notes
Working dilution: Optimal dilutions should be determined by the end user. The following are guidelines only: WB1:500-1:1,000 Positive control: Mouse brain
Restrictions
For Research Use only
Handling
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Buffer
PBS, pH 7.4
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Dilute in PBS or medium which is identical to that used in the assay system.
Storage
-20 °C
Storage Comment
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
Target Details for APP
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Target
APP
(Amyloid beta (A4) Precursor Protein (APP))
Alternative Name
APP (APP Products )
Synonyms
AAA antibody, ABETA antibody, ABPP antibody, AD1 antibody, APPI antibody, CTFgamma antibody, CVAP antibody, PN-II antibody, PN2 antibody, aaa antibody, abeta antibody, abpp antibody, ad1 antibody, appi antibody, ctfgamma antibody, cvap antibody, pn2 antibody, APP antibody, APP-like antibody, APPL antibody, Abeta antibody, BcDNA:GH04413 antibody, CG7727 antibody, Dmel\\CG7727 antibody, EG:65F1.5 antibody, appl antibody, Abpp antibody, Adap antibody, Ag antibody, Cvap antibody, E030013M08Rik antibody, betaApp antibody, app antibody, wu:fj34d10 antibody, wu:fk65e12 antibody, zgc:85740 antibody, amyloid beta precursor protein antibody, amyloid beta (A4) precursor protein antibody, beta amyloid protein precursor-like antibody, amyloid beta (A4) precursor protein a antibody, amyloid beta precursor protein L homeolog antibody, APP antibody, app antibody, Appl antibody, App antibody, appa antibody, app.L antibody
Background
Accumulation of the amyloid-β peptide (Aβ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The β-amyloid protein precursor (APP) is cleaved by β-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for γ-secretase to generate the 4 kD amyloid-β peptide which is deposited in the brain. Amyloid beta A4 protein BPP APPI, APP Alzheimer disease amyloid protein Cerebral vascular amyloid peptide, CVAP PreA4 Protease nexin-II, PN-II Gene name: APP, A4, AD1
UniProt
P05067
Pathways
Caspase Cascade in Apoptosis , EGFR Signaling Pathway , Transition Metal Ion Homeostasis , Skeletal Muscle Fiber Development , Toll-Like Receptors Cascades , Feeding Behaviour
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