PINK1 antibody (AA 258-274)

Catalog No. ABIN1738112

Product Details anti-PINK1 Antibody

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Binding Specificity: AA 258-274

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PINK1 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: Reacts with human PINK1.

Purification: Purified

Immunogen: Synthetic peptide corresponding to amino acids 258-274 (YRKSKRGPKQLAPHPNI) of human PINK1 conjugated to KLH.

Isotype: IgG

Application Details

Application Notes: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
WB 1:500 dilution

Positive control: Transfected cell lines

Restrictions: For Research Use only

Handling

Buffer: PBS, pH 7.4,

Handling Advice: Dilute in PBS or medium which is identical to that used in the assay system.

Storage: 4 °C/-20 °C

Storage Comment: Short term storage at+4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 months from date of receipt.

Expiry Date: 6 months

Target Details for PINK1

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Alternative Name: PINK1 (PINK1 Products)

Synonyms: BEST:GH23468 antibody, CG4523 antibody, Dmel\\CG4523 antibody, PINK antibody, PINK1 antibody, dPINK1 antibody, dPink1 antibody, pink1 antibody, wu:fc39e12 antibody, zgc:101729 antibody, BRPK antibody, PARK6 antibody, 1190006F07Rik antibody, AU042772 antibody, AW557854 antibody, mFLJ00387 antibody, PTEN-induced putative kinase 1 antibody, PTEN induced putative kinase 1 antibody, Pink1 antibody, PINK1 antibody, pink1 antibody

Background: PTEN induced putative kinase 1 (Pink1) was first discovered when researching the PTEN signaling pathway, thus Pink1 is also involved in many human cancers.It is found in the mitochondria and its homozygous C-terminus mutation has been implicated in the early development of Parkinson's disease. It protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2.

Serine/threonine-protein kinase PINK1, mitochondrial BRPK PTEN-induced putative kinase protein 1 Gene name: PINK1

Gene ID: 65018

UniProt: Q9BXM7

Pathways: Autophagy