CLEC7A antibody
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- Target See all CLEC7A Antibodies
- CLEC7A (C-Type Lectin Domain Family 7, Member A (CLEC7A))
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Reactivity
- Mouse
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Host
- Rat
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Clonality
- Monoclonal
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Conjugate
- This CLEC7A antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificity
- Recognizes murine beta-glucan receptor, also known as Dectin-1. Dectin-1 is predominantly expressed by cells of the monocyte/macrophage and neutrophil lineages, but also at lower levels by dendritic cells and a subpopulation of T cells. As a major leucocyte receptor for beta-glucan this molecule may have a key role in the immunomodulatory effects of beta-glucans and in the host response to fungal pathogens. Recent work has shown that Dectin-1 may stimulate reactive oxygen production in macrophages via the protein tyrosine kinase known as Syk. Inhibits the binding of zymosan to macrophages via the beta-glucan receptor. The low endotoxin version is recommended for functional studies.
- Purification
- Protein G purified
- Immunogen
- Dectin-1 transfected NIH3T3 cells and recombinant soluble Dectin-1.
- Clone
- 2A11
- Isotype
- IgG2b
- Top Product
- Discover our top product CLEC7A Primary Antibody
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- Application Notes
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Approved: Flo (1:10 - 1:50), IHC, IHC-Fr, IP
Not recommended for: IHC-P, IHC-R - Comment
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Target Species of Antibody: Mouse
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- PBS, 0.09 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- 4°C or -20°C, Avoid freeze-thaw cycles.
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- Target
- CLEC7A (C-Type Lectin Domain Family 7, Member A (CLEC7A))
- Alternative Name
- CLEC7A / Dectin 1 (CLEC7A Products)
- Synonyms
- CLEC7A antibody, BGR antibody, Clecsf12 antibody, beta-GR antibody, CANDF4 antibody, CLECSF12 antibody, DECTIN1 antibody, Clec7b antibody, RGD1565140 antibody, C-type lectin domain containing 7A antibody, C-type lectin domain family 7, member a antibody, CLEC7A antibody, Clec7a antibody
- Background
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Name/Gene ID: CLEC7A
Synonyms: CLEC7A, BGR, CANDF4, CLECSF12, Dectin-1, DC-associated C-type lectin 1, DECTIN1, HDectin-1, Beta-glucan receptor, Lectin-like receptor 1 - Gene ID
- 64581
- Pathways
- Activation of Innate immune Response
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