TREM1 antibody

Catalog No. ABIN1819860

Product Details anti-TREM1 Antibody

Target: TREM1 (Triggering Receptor Expressed On Myeloid Cells 1 (TREM1))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This TREM1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)

Specificity: Recognizes mouse triggering receptor expressed on myeloid cells 1 (TREM-1), a 30kD member of the immunoglobulin superfamily expressed on neutrophils and a subset of monocytes. TREM-1 is involved in the microbial inflammatory response. It acts in conjunction with the adaptor protein DAP12 to activate neutrophils and monocytes, leading to the secretion of pro-inflammatory mediators and enhancement of the inflammatory response. Microbial infection also induces the release of soluble form of TREM-1 from monocytes, which is reported to act as an inhibitor of TREM-1. TREM-1 mediates the septic shock pathway, and blocking TREM-1 has been reported to reduce inflammation and increase survival in certain models of bacterial infection.

Purification: Protein G purified

Immunogen: Mouse TREM-1 Fc fusion protein.
Immunogen type: Fusion protein

Clone: L5-B8-2A12-3A12

Isotype: IgG2a

Application Details

Application Notes: Flo (1:25 - 1:100), IF, IHC-Fr, WB

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Target Details for TREM1

Target: TREM1 (Triggering Receptor Expressed On Myeloid Cells 1 (TREM1))

Alternative Name: TREM1 / TREM-1 (TREM1 Products)

Synonyms: TREM1 antibody, CD354 antibody, TREM-1 antibody, triggering receptor expressed on myeloid cells 1 antibody, TREM1 antibody, Trem1 antibody, LOC100349504 antibody

Background: Synonyms :
TREM1, CD354, CD354 antigen, Triggering-receptor TREM1, TREM-1

Gene ID: 54210

UniProt: Q9NP99