Checkpoint Kinase 1 (CHEK1) (Middle Region) antibody

Details for Product No. ABIN182614
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Antigen
Synonyms An08g10320, AO090003000441, CHK1, chk1, C85740, Chk1, rad27, id:ibd2720, zgc:56093, CHEK1
Epitope
Middle Region
(50), (42), (32), (32), (20), (14), (11), (9), (9), (5), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Zebrafish (Danio rerio), Xenopus laevis, Human, Chicken
(395), (132), (124), (36), (25), (25), (13), (4), (3), (2), (1), (1), (1)
Host
Rabbit
(347), (39), (12), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (9), (9), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(310), (158), (98), (58), (50), (50), (26), (21), (11), (4), (2), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN182614
289.00 $
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Immunogen Synthetic peptide directed towards the middle region of human CHEK1
Sequence WSCGIVLTAM LAGELPWDQP SDSCQEYSDW KEKKTYLNPW KKIDSAPLAL
Predicted Reactivity Dog : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Bovine : 90 %, Chicken : 90 %, Guinea pig : 90 %, Pig : 90 %, Zebrafish : 70 %
Characteristics This is a rabbit polyclonal antibody against CHEK1. It was validated on Western Blot and immunohistochemistry.
Purification Affinity Purified
Alternative Name CHEK1
Background CHEK1 is required during normal S phase to avoid aberrantly increased initiation of DNA replication, thereby protecting against DNA breakage. Its expression is dispensable for somatic cell death and critical for sustaining G2 DNA damage checkpoint.
Molecular Weight 54 kDa
Gene ID 1111
NCBI Accession NP_001265, NM_001274
UniProt O14757
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 476 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Checkpoint Kinase 1 (CHEK1) (Middle Region) antibody WB Suggested Anti-CHEK1 Antibody Titration: 0.2-1 ug/ml
Positive Control: HepG2 cell lysate
anti-Checkpoint Kinase 1 (CHEK1) (Middle Region) antibody (2) anti-Checkpoint Kinase 1 (CHEK1) (Middle Region) antibody (Image 2)
Background publications Krämer, Mailand, Lukas et al.: "Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase." in: Nature cell biology, Vol. 6, Issue 9, pp. 884-91, 2004 (PubMed).

Validation Images
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