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Details for Product No. ABIN182681

Prohibitin (PHB) (C-Term) antibody

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Antigen
Synonyms PHB1, Bap32, sr:nyz128, wu:fa18f07, wu:fb09f05, phb1, prohibitin1, xphb1, MGC75944, PHB, Phb, ACYPI000080, phb
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Xenopus laevis, Zebrafish (Danio rerio), Human, Chicken
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 1 reference available
Catalog no. ABIN182681
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Immunogen The immunogen for anti-PHB antibody: synthetic peptide directed towards the C terminal of human PHB
Sequence AEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLE AAEDIAYQLS
Predicted Reactivity Bovine : 100%, Chicken : 100%, Dog : 100%, Human : 100%, Mouse : 100%, Rat : 100%, African clawed frog : 85%, Zebrafish : 85%
Characteristics This is a rabbit polyclonal antibody against PHB. It was validated on Western Blot and immunohistochemistry. We manufacture rabbit polyclonal antibodies on a large scale of high throughput manner. Our antibodies are peptide based and protein family oriented.
Purification Affinity Purified
Alternative Name PHB
Background Prohibitin is from an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.
Molecular Weight 30kDa
Gene ID 5245
NCBI Accession NP_002625, NM_002634
UniProt P35232
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-PHB antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Fraering, Ye, Strub et al.: "Purification and characterization of the human gamma-secretase complex." in: Biochemistry, Vol. 43, Issue 30, pp. 9774-89, 2004 (PubMed).

Alternatives for antigen "Prohibitin (PHB)", type "Antibodies"
Hosts (85), (33)
Reactivities (92), (52), (42), (12), (4), (3), (3), (2), (2)
Applications (97), (50), (38), (28), (24), (19), (13), (11), (10), (5), (2), (1), (1)
Conjugates (8), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (15), (6), (4), (4), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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