Prohibitin (PHB) (C-Term) antibody

Details for Product No. ABIN182681
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Antigen
Synonyms phb1, MGC75944, PHB, Phb, ACYPI000080, phb, PHB1, Bap32, sr:nyz128, wu:fa18f07, wu:fb09f05, prohibitin1, xphb1
Epitope
C-Term
(27), (12), (4), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Xenopus laevis, Zebrafish (Danio rerio), Human, Chicken
(106), (57), (39), (12), (4), (2), (2)
Host
Rabbit
(101), (31)
Clonality
Polyclonal
Conjugate
Un-conjugated
(11), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(111), (51), (48), (33), (31), (16), (13), (10), (9), (5), (1), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN182681
289.00 $
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Immunogen Synthetic peptide directed towards the C terminal of human PHB
Sequence AEQQKKAAII SAEGDSKAAE LIANSLATAG DGLIELRKLE AAEDIAYQLS
Predicted Reactivity Bovine : 100 %, Chicken : 100 %, Dog : 100 %, Human : 100 %, Mouse : 100 %, Rat : 100 %, African clawed frog : 80 %, Zebrafish : 80 %
Characteristics This is a rabbit polyclonal antibody against PHB. It was validated on Western Blot and immunohistochemistry.
Purification Affinity Purified
Alternative Name PHB
Background Prohibitin is from an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.
Molecular Weight 30 kDa
Gene ID 5245
NCBI Accession NM_002634, NP_002625
UniProt P35232
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 272 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Prohibitin (PHB) (C-Term) antibody WB Suggested Anti-PHB Antibody Titration: 0.2-1 ug/ml
Positive Control: Jurkat cell lysate
anti-Prohibitin (PHB) (C-Term) antibody (2) anti-Prohibitin (PHB) (C-Term) antibody (Image 2)
Background publications Fraering, Ye, Strub et al.: "Purification and characterization of the human gamma-secretase complex." in: Biochemistry, Vol. 43, Issue 30, pp. 9774-89, 2004 (PubMed).

Validation Images
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