anti-Prohibitin antibody (PHB) (C-Term)

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Antigen
Synonyms phb1, MGC75944, PHB, Phb, ACYPI000080, phb, PHB1, Bap32, sr:nyz128, wu:fa18f07, wu:fb09f05, prohibitin1, xphb1
Epitope
C-Term
(41), (26), (6), (4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Chicken, Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus), Xenopus laevis, Zebrafish (Danio rerio)
(175), (62), (45), (3), (2), (1), (1)
Host
Rabbit
(161), (38)
Clonality
Polyclonal
Conjugate
This Prohibitin antibody is un-conjugated
(17), (10), (8), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(158), (82), (61), (57), (40), (26), (17), (12), (11), (6), (5), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the C terminal of human PHB
Blocking Peptide Blocking peptide for this product available: Prohibitin (PHB) peptide (ABIN981663)
Sequence AEQQKKAAII SAEGDSKAAE LIANSLATAG DGLIELRKLE AAEDIAYQLS
Predicted Reactivity Bovine : 100 %, Chicken : 100 %, Dog : 100 %, Human : 100 %, Mouse : 100 %, Rat : 100 %, African clawed frog : 80 %, Zebrafish : 80 %
Characteristics This is a rabbit polyclonal antibody against PHB. It was validated on Western Blot and immunohistochemistry.
Purification Affinity Purified
Alternative Name PHB (PHB Antibody Abstract)
Background Prohibitin is from an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.
Molecular Weight 30 kDa
Gene ID 5245
NCBI Accession NM_002634, NP_002625
UniProt P35232
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 272 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Prohibitin antibody (PHB) (C-Term) (ABIN182681) WB Suggested Anti-PHB Antibody Titration: 0.2-1 ug/ml
Positive Control: ...
Immunohistochemistry (IHC) image for anti-Prohibitin antibody (PHB) (C-Term) (ABIN182681) anti-Prohibitin (PHB) (C-Term) antibody (Image 2)
Background publications Fraering, Ye, Strub et al.: "Purification and characterization of the human gamma-secretase complex." in: Biochemistry, Vol. 43, Issue 30, pp. 9774-89, 2004 (PubMed).

Catalog No. ABIN182681
$289.00
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