Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN184024

Non-POU Domain Containing, Octamer-Binding (NONO) (C-Term) antibody

Request
Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms AA407051, AV149256, NRB54, P54NRB, nonA, nmt55, nrb54, p54nrb, xp54nrb, P54, NMT55
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Dog (Canine), Mouse (Murine), Rat (Rattus), Cow (Bovine), Xenopus laevis, Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Pubmed 2 references available
Catalog no. ABIN184024
Quantity 100 µg
Price
229.00 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-NONO antibody: synthetic peptide directed towards the C terminal of human NONO
Sequence DGTLGLTPPTTERFGQAATMEGIGAIGGTPPAFNRAAPGA EFAPNKRRRY
Predicted Reactivity Bovine : 100%, Horse : 100%, Human : 100%, Rabbit : 100%, Mouse : 92%, Rat : 92%, African clawed frog : 76%
Characteristics This is a rabbit polyclonal antibody against NONO. It was validated on Western Blot and immunohistochemistry. We manufacture rabbit polyclonal antibodies on a large scale of high throughput manner. Our antibodies are peptide based and protein family oriented.
Purification Protein A purified
Alternative Name NONO
Background NONO is DNA- and RNA binding protein, involved in several nuclear processes. It binds the conventional octamer sequence in double stranded DNA. It also binds single-stranded DNA and RNA at a site independent of the duplex site. It is involved in pre-mRNA splicing and interacts with U5 snRNA. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs, be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 and be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription.
Molecular Weight 52kDa
Gene ID 4841
NCBI Accession NP_031389, NM_007363
UniProt Q15233
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-NONO antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Product cited in: Lazrek, Goffard, Schanen et al.: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." in: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, 2006 (PubMed).

Background publications Kimura, Wakamatsu, Suzuki et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

Alternatives for antigen "Non-POU Domain Containing, Octamer-Binding (NONO)", type "Antibodies"
Hosts (26), (10), (7)
Reactivities (37), (12), (10), (5), (2), (2), (1), (1), (1)
Applications (42), (14), (13), (10), (7), (6), (5), (1), (1)
Conjugates (1)
Epitopes (6), (5), (4), (3), (3), (2), (1), (1), (1), (1)
Beacon