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ADAM17 antibody (ADAM Metallopeptidase Domain 17) (C-Term)

Details for Product anti-ADAM17 Antibody No. ABIN184721, Supplier: Log in to see
Antigen
  • TACE
  • adam17
  • si:dkey-81b15.2
  • adam18
  • cd156b
  • csvp
  • tace
  • CD156b
  • Tace
  • ADAM18
  • CD156B
  • CSVP
  • NISBD
  • ADAM metallopeptidase domain 17
  • a disintegrin and metallopeptidase domain 17b
  • a disintegrin and metallopeptidase domain 17
  • ADAM17
  • adam17b
  • adam17
  • Adam17
Alternatives
anti-Human ADAM17 antibody for Western Blotting
Epitope
C-Term
75
18
16
14
12
12
10
10
9
8
7
6
5
5
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
251
79
69
2
2
2
1
1
1
1
Host
Goat
172
62
23
1
1
Clonality
Polyclonal
Conjugate
This ADAM17 antibody is un-conjugated
10
8
8
6
6
6
5
5
5
5
5
5
5
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Method Type
Peptide ELISA
Application
ELISA, Western Blotting (WB)
191
112
82
32
27
14
14
13
11
5
2
2
1
1
Options
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Immunogen Peptide with sequence LQRQNRVDSKETEC, from the C Terminus of the protein sequence according to NP_003174.3.
Blocking Peptide Blocking peptide for this product available: ABIN370239
Specificity This antibody is expected to recognise isoform 1 (represented by NP_003174) and not isoform 2 (represented by NP_068604).
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name ADAM17 / TACE (ADAM17 Antibody Abstract)
Background Synonyms: ADAM17, TACE, a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme), CSVP, cSVP, CD156b, CD156b, MGC71942, TACE, cSVPADAM metallopeptidase domain 17, TNF-alpha converting enzyme, a disintegrin and metalloproteinase domain 17, a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme), snake venom-like protease, ADAM metallopeptidase domain 17, ADAM18, CD156B, ADAM metallopeptidase domain 18, snake venom-like protease, tumor necrosis factor, alpha, converting enzyme
Gene ID 6868, 11491
NCBI Accession NP_003174
Pathways Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus
Application Notes ELISA: antibody detection limit dilution 1:128000.
Western blot: Approx 100 kDa band observed in human testis lysates (calculated MW of 93.0 kDa according to NP_003174.3). Recommended concentration: 0.1-0.3 µg/mL.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Supplier Images
Western Blotting (WB) image for anti-ADAM17 antibody (ADAM Metallopeptidase Domain 17) (C-Term) (ABIN184721) ABIN184721 staining (0.2µg/ml) of Hela lysate (RIPA buffer, 35µg total protein per la...
Background publications Black, Rauch, Kozlosky, Peschon, Slack, Wolfson, Castner, Stocking, Reddy, Srinivasan, Nelson, Boiani, Schooley, Gerhart, Davis, Fitzner, Johnson, Paxton, March, Cerretti: "A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells." in: Nature, Vol. 385, Issue 6618, pp. 729-33, 1997 (PubMed).