NLR Family, Pyrin Domain Containing 3 (NLRP3) (C-Term) antibody

Antigen: NLR Family, Pyrin Domain Containing 3 (NLRP3)

Synonyms: AII, AVP, FCU, MWS, FCAS, CIAS1, NALP3, C1orf7, CLR1.1, PYPAF1, AII/AVP, AGTAVPRL, FLJ95925, Cias1, Mmig1, Pypaf1, MGC129375, NLRP3, MGC159873, avp, cias1, nalp3, pypaf1, agtavprl

Binding Site: C-Term

Clonality: Polyclonal

Host: Goat

Reactivity: Please enquire

Conjugate: Un-conjugated

Application: ELISA

Catalog no.: ABIN184887

Additional Information

Alternative name: CIAS1 / cryopyrin

Gene ID: 114548

Immunogen: C-EKPELTVVFEPSW

Description: All names and symbols: CIAS1, FCU, MWS, FCAS, NALP3, C1orf7, PYPAF1, AII/AVP, AGTAVPRL, CRYOPYRIN, cold autoinflammatory syndrome 1, cryopyrin, Muckle-Wells syndrome, chromosome 1 open reading frame 7, PYRIN-containing APAF1-like protein 1, neuronal apoptosis inhibitor protein 3, angiotensin/vasopressin receptor AII/AVP-like. Official Symbol: CIAS1. RefSeq number(s): NP_004886. Gene ontology terms: hearing, induction of apoptosis, signal transduction, inflammatory response, cellular_component unknown, apoptosis activator activity

Specificity: Human, Rat 1034 aa

Application Details

Application Notes: Peptide ELISA: antibody detection limit dilution >1:32000. Western Blot: No signal obtained yet but low background observed in Daudi, A431, Jurkat, U937 and MOLT-4 lysates at up to 1µg/ml. We would appreciate any feedback from people in the field - have any results been reported with other antibodies/lysates?

Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Buffer: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Storage: Aliquot and store at -20°C. Minimize freezing and thawing.

Restrictions: For Research Use only

Publications

Hoffman, Mueller, Broide et al.: "Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome." in: Nature genetics, Vol. 29, Issue 3, pp. 301-5, 2001 (PubMed).