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NLR Family, Pyrin Domain Containing 3 (NLRP3) (C-Term) antibody

Details for Product No. ABIN184887
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Antigen
Synonyms CIAS1, Nalp3, avp, cias1, nalp3, pypaf1, agtavprl, AGTAVPRL, AII, AVP, C1orf7, CLR1.1, FCAS, FCU, MWS, NALP3, PYPAF1, AII/AVP, Cias1, Mmig1, Pypaf1
Epitope
C-Term
(23), (7), (5), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(93), (37), (30), (16), (5), (2)
Host
Goat
(59), (19), (16), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Methode Type Peptide ELISA
Application
ELISA, Western Blotting (WB)
(63), (39), (21), (20), (14), (7), (7), (6), (3), (2), (2), (1)
Pubmed 1 reference available
Quantity 100 µg
Options
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Availability Available
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Catalog No. ABIN184887
374.27 $
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Immunogen Peptide with sequence C-EKPELTVVFEPSW, from the C Terminus of the protein sequence according to NP_001073289.1, NP_004886.3, NP_899632.1, NP_001120933.1, NP_001120934.1.
Specificity Variants (NP_001073289.1, NP_004886.3) encode the same isoform.
Cross-Reactivity Rat (Rattus), Cow (Bovine)
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name CIAS1 / cryopyrin
Background Synonyms: NLRP3, CIAS1, FCU, MWS, FCAS, NALP3, C1orf7, PYPAF1, AII/AVP, AGTAVPRL, CRYOPYRIN, cold autoinflammatory syndrome 1, cryopyrin, Muckle-Wells syndrome, chromosome 1 open reading frame 7, PYRIN-containing APAF1-like protein 1, neuronal apoptosis inhibitor protein 3, angiotensin/vasopressin receptor AII/AVP-like, NLR family, pyrin domain containing 3, AII, AVP, CLR1.1, FLJ95925, AII/AVP receptor-like, NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3, NACHT, LRR and PYD containing protein 3, PYRIN-containing APAF1-like protein 1, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
Gene ID 114548
NCBI Accession NP_001073289.1, NP_004886.3, NP_899632.1, NP_001120933.1, NP_001120934.1
Application Notes ELISA: antibody detection limit dilution 1:32000.
Western blot: No signal obtained yet but low background observed in A431 lysates at up to 1 µg/mL. Flow cytometry: Customer finds it to work well in FC on human monocytes.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
General Hoffman, Mueller, Broide et al.: "Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome." in: Nature genetics, Vol. 29, Issue 3, pp. 301-5, 2001 (PubMed).

Validation Images
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