Spleen tyrosine Kinase (SYK) (Internal Region) antibody

Details for Product No. ABIN185423
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Antigen
Synonyms p72-Syk, Sykb, p72syk
Epitope
Internal Region
(43), (29), (23), (19), (12), (9), (8), (8), (7), (7), (7), (7), (6), (6), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(266), (110), (103), (37), (27), (25), (12), (12), (3), (1)
Host
Goat
(213), (52), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (6), (6), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Methode Type Peptide ELISA
Application
ELISA, Western Blotting (WB)
(213), (100), (95), (76), (47), (45), (30), (29), (3), (2), (1), (1)
Pubmed 2 references available
Quantity 100 μg
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Catalog No. ABIN185423
374.27 $
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Immunogen Peptide with sequence C-KYLQQNRHVKDKN, from the internal region of the protein sequence according to NP_003168.2, NP_001128524.1.
Specificity This antibody is expected to recognise both reported isoforms (NP_003168.2, NP_001128524.1). Reported pairs of variants represent identical proteins (NP_003168.2 and NP_001167638.1, NP_001128524.1 and NP_001167639.1).
Cross-Reactivity Mouse (Murine), Rat (Rattus), Dog (Canine), Pig (Porcine), Cow (Bovine)
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name Spleen tyrosine kinase / SYK
Background Synonyms: SYK, spleen tyrosine kinase, HGNC:11491, DKFZp313N1010, FLJ25043, FLJ37489, OTTHUMP00000021628, OTTHUMP00000021629
Gene ID 6850, 20963, 25155
NCBI Accession NP_003168, NP_001128524
Application Notes ELISA: antibody detection limit dilution 1:16000.
Western blot: Approx 70 kDa band observed in Human Bone marrow, Lymph Node, and Spleen lysates (calculated MW of 72.1 kDa according to NP_003168.2). Recommended concentration: 1-3 µg/mL.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Supplier Images
anti-Spleen tyrosine Kinase (SYK) (Internal Region) antibody ABIN185423 (1µg/ml) staining of Human Spleen lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
General Rogers, Slack, Edwards et al.: "Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins." in: Immunity, Vol. 22, Issue 4, pp. 507-17, 2005 (PubMed).

Underhill, Rossnagle, Lowell et al.: "Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production." in: Blood, Vol. 106, Issue 7, pp. 2543-50, 2005 (PubMed).

Validation Images
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