Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) (C-Term) antibody

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Antigen
  • trpc6
  • FSGS2
  • TRP6
  • AV025995
  • LLHWJM002
  • LLHWJM003
  • LLHWJM004
  • TRP-6
  • Trrp6
  • mtrp6
  • trp6
  • bZ1P14.9
  • si:rp71-1p14.9
  • transient receptor potential cation channel, subfamily C, member 6
  • transient receptor potential cation channel, subfamily C, member 6a
  • TRPC6
  • trpc6
  • Trpc6
  • trpc6a
Epitope
C-Term
44
21
6
3
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine)
102
60
36
7
5
4
3
3
3
2
2
1
1
1
Host
Goat
78
40
7
1
1
1
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
4
4
4
Method Type
Peptide ELISA
Application
ELISA, Western Blotting (WB)
104
59
33
15
11
6
6
5
4
1
Options
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Immunogen Peptide with sequence C-EKLSMEPNQEETN, from the C Terminus of the protein sequence according to NP_004612.2.
Blocking Peptide Blocking peptide for this product available: ABIN369006
Cross-Reactivity Human, Dog (Canine), Pig (Porcine), Cow (Bovine)
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name TRPC6 (TRPC6 Antibody Abstract)
Background Synonyms: TRPC6, transient receptor potential cation channel, subfamily C, member 6, HGNC:12338, TRP6, transient receptor potential channel 6, FLJ11098, FLJ14863, FSGS2, TRP6
Gene ID 7225
NCBI Accession NP_004612
Research Area Signaling
Application Notes ELISA: antibody detection limit dilution 1:2000.
Western blot: Preliminary experiments gave an approx 80 kDa band in Human Spleen and Testis lysates after 1 µg/mL antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 106 kDa according to NP_004612.2. The 80 kDa band was successfully blocked by incubation with the immunizing peptide. Flow cytometry: This antibody has been proven to specifically react to TRPC6 in FC.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Background publications Winn, Conlon, Lynn, Farrington, Creazzo, Hawkins, Daskalakis, Kwan, Ebersviller, Burchette, Pericak-Vance, Howell, Vance, Rosenberg: "A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis." in: Science (New York, N.Y.), Vol. 308, Issue 5729, pp. 1801-4, 2005 (PubMed).

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