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Tryptophan Hydroxylase 2 antibody (TPH2) (Internal Region)

Details for Product anti-TPH2 Antibody No. ABIN185533, Supplier: Login to see
Antigen
  • tph2
  • tph1l
  • tphD2
  • ADHD7
  • NTPH
  • AU043594
  • Ntph
  • tphR
  • wu:fq15a04
Epitope
Internal Region
31
27
13
13
12
11
10
6
3
2
1
1
1
1
1
1
1
1
1
Reactivity
Human
92
50
44
10
9
4
3
2
1
1
1
1
1
Host
Goat
80
38
1
Clonality
Polyclonal
Conjugate
This Tryptophan Hydroxylase 2 antibody is un-conjugated
6
5
5
5
5
4
2
1
1
1
1
1
1
1
1
Methode Type
Peptide ELISA
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
82
63
36
14
12
10
3
3
2
1
1
1
Supplier
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Immunogen Peptide with sequence C-NKPNSGKNDDKGNK, from the internal region of the protein sequence according to NP_775489.2.
Blocking Peptide Blocking peptide for this product available: ABIN369473
Cross-Reactivity Dog (Canine), Pig (Porcine), Cow (Bovine)
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name Tryptophan hydroxylase 2 / TPH2 (TPH2 Antibody Abstract)
Background Synonyms: TPH2, tryptophan hydroxylase 2, HGNC:20692, FLJ37295, NTPH, neuronal tryptophan hydroxylase, ADHD7, MGC138871, MGC138872, tryptophan 5-monooxygenase 2
Gene ID 121278
NCBI Accession NP_775489
Pathways
Application Notes ELISA: antibody detection limit dilution 1:16000.
Western blot: Preliminary experiments in human brain lysates gave no specific signal but low background (at antibody concentration up to 1 µg/mL).
IHC: In paraffin embedded Human Brain Stem shows layered neuronal staining. Recommended concentration: 4-6 µg/mL.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Background publications Zhou, Roy, Lipsky et al.: "Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations." in: Archives of general psychiatry, Vol. 62, Issue 10, pp. 1109-18, 2005 (PubMed).