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Tryptophan Hydroxylase 2 antibody (TPH2) (Internal Region)

Details for Product anti-TPH2 Antibody No. ABIN185533, Supplier: Login to see New
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Antigen
Synonyms tph2, tph1l, tphD2, ADHD7, NTPH, AU043594, Ntph, tphR, wu:fq15a04
Epitope
Internal Region
(31), (27), (13), (13), (12), (11), (10), (6), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(92), (50), (44), (10), (9), (4), (3), (2), (1), (1), (1), (1), (1)
Host
Goat
(80), (38), (1)
Clonality
Polyclonal
Conjugate
This Tryptophan Hydroxylase 2 antibody is un-conjugated
(6), (5), (5), (5), (5), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Methode Type Peptide ELISA
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
(82), (63), (36), (14), (12), (10), (3), (3), (2), (1), (1), (1)
Pubmed 1 reference available
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Quantity 100 μg
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Immunogen Peptide with sequence C-NKPNSGKNDDKGNK, from the internal region of the protein sequence according to NP_775489.2.
Blocking Peptide Blocking peptide for this product available: ABIN369473
Cross-Reactivity Dog (Canine), Pig (Porcine), Cow (Bovine)
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name Tryptophan hydroxylase 2 / TPH2 (TPH2 Antibody Abstract)
Background Synonyms: TPH2, tryptophan hydroxylase 2, HGNC:20692, FLJ37295, NTPH, neuronal tryptophan hydroxylase, ADHD7, MGC138871, MGC138872, tryptophan 5-monooxygenase 2
Gene ID 121278
NCBI Accession NP_775489
Pathways
Application Notes ELISA: antibody detection limit dilution 1:16000.
Western blot: Preliminary experiments in human brain lysates gave no specific signal but low background (at antibody concentration up to 1 µg/mL).
IHC: In paraffin embedded Human Brain Stem shows layered neuronal staining. Recommended concentration: 4-6 µg/mL.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Background publications Zhou, Roy, Lipsky et al.: "Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations." in: Archives of general psychiatry, Vol. 62, Issue 10, pp. 1109-18, 2005 (PubMed).

Catalog No. ABIN185533
$318.20
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