CASQ2 antibody (AA 79-107)

Catalog No. ABIN1881138

Product Details anti-CASQ2 Antibody

Target: CASQ2 (Calsequestrin 2 (CASQ2))

Binding Specificity: AA 79-107

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CASQ2 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: Rb

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CASQ2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-107 amino acids from the Central region of human CASQ2.

Clone: RB41817

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CASQ2 antibody (ABIN1881138)

Kirchhefer, Wehrmeister, Postma, Pohlentz, Mormann, Kucerova, Müller, Schmitz, Schulze-Bahr, Wilde, Neumann: "The human CASQ2 mutation K206N is associated with hyperglycosylation and altered cellular calcium handling." in: Journal of molecular and cellular cardiology, Vol. 49, Issue 1, pp. 95-105, (2010) (PubMed).

Wei, Hanna, Beard, Dulhunty: "Unique isoform-specific properties of calsequestrin in the heart and skeletal muscle." in: Cell calcium, Vol. 45, Issue 5, pp. 474-84, (2009) (PubMed).

Target Details for CASQ2

Target: CASQ2 (Calsequestrin 2 (CASQ2))

Alternative Name: CASQ2 (CASQ2 Products)

Synonyms: CASQ2 antibody, DKFZp468D075 antibody, AA033488 antibody, AW146219 antibody, ESTM52 antibody, cCSQ antibody, PDIB2 antibody, cardCSQ antibody, CASQ1 antibody, CAL antibody, calsequestrin 2 antibody, CASQ2 antibody, Casq2 antibody

Background: The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest. [provided by RefSeq].

Molecular Weight: 46436

NCBI Accession: NP_001223

UniProt: O14958

Pathways: Negative Regulation of Transporter Activity