Cyclin D3 antibody (CCND3) (pSer264)

Details for Product anti-CCND3 Antibody No. ABIN1881180, Supplier: Log in to see
Antigen
  • zgc:103502
  • CCND3
  • 9230106B05Rik
  • AA682053
  • AL024085
  • AW146355
  • C78795
  • cyclin D3
  • ccnd3
  • CCND3
  • Ccnd3
Alternatives
anti-Human Cyclin D3 antibody for Immunohistochemistry (Frozen Sections)
Epitope
pSer264
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Reactivity
Human
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Host
Rabbit
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Clonality (Clone)
Polyclonal ()
Conjugate
This Cyclin D3 antibody is un-conjugated
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Application
Dot Blot (DB)
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Options
Supplier
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Supplier Product No.
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Immunogen This CCND3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S264 of human CCND3.
Clone RB42160
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name CCND3 (CCND3 Antibody Abstract)
Background The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.

Synonyms: CCND3, G1/S-specific cyclin-D3
NCBI Accession NP_001129597, NP_001751, NP_001129489, NP_001129598
UniProt P30281
Pathways Cell Division Cycle, Mitotic G1-G1/S Phases, Glycosaminoglycan Metabolic Process
Application Notes DB: 1:500
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Dot Blot (DB) image for anti-Cyclin D3 (CCND3) (pSer264) antibody (ABIN1881180) Dot blot analysis of CCND3 Antibody (Phospho S264) Phospho-specific Pab (ABIN1881180)...
Product cited in: Kim, Kim, Ko: "CKbeta8/CCL23 and its isoform CKbeta8-1 induce up-regulation of cyclins via the G(i)/G(o) protein/PLC/PKCdelta/ERK leading to cell-cycle progression." in: Cytokine, Vol. 50, Issue 1, pp. 42-9, 2010 (PubMed).

Gumina, Xu, Chiles: "Cyclin D3 is dispensable for human diffuse large B-cell lymphoma survival and growth: evidence for redundancy with cyclin E." in: Cell cycle (Georgetown, Tex.), Vol. 9, Issue 4, pp. 820-8, 2010 (PubMed).

Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010 (PubMed).

Kamatani, Matsuda, Okada, Kubo, Hosono, Daigo, Nakamura, Kamatani: "Genome-wide association study of hematological and biochemical traits in a Japanese population." in: Nature genetics, Vol. 42, Issue 3, pp. 210-5, 2010 (PubMed).